Presentation
In this paper, the authors present a case study of a patient whose nystagmus has a strong and exclusive male hereditary component. Genetic argumentation is presented in support of this conclusion. [ncbi.nlm.nih.gov]
It is present physiologically in everyone to a minor degree under certain conditions but it is often pathologic when exaggerated movements are present during normal visual activities. [disorders.eyes.arizona.edu]
The signs and symptoms of neurological disease are elusive by their very nature, presenting a confounding diagnostic challenge. [books.google.com]
Inheritance - congenital achromatopsia is transmitted in an autosomal-recessive trait Presentation - patients present in early childhood with nystagmus, abnormal visual behaviour or photophobia. Acuity is less than 20/200. [patient.info]
Entire Body System
- Movement Disorder
We work with people of all ages who have eye movement disorders. Our goal is to identify the cause of your eye movement disorder and help you receive the most effective treatment. [dukehealth.org]
It is a type of bilateral involuntary eye movement disorder usually manifest as a slow movement in one direction and a rapid motion in the other direction. [disorders.eyes.arizona.edu]
Children with eye movement disorders are monitored closely with repeat testing while they are young. Genetic Testing Genetic testing and counseling is available to the parents of children with eye movement disorders that are linked to heredity. [shileyeye.ucsd.edu]
vision loss (5-15%) Loss of position and vibration sense (posterior column degeneration) Distal weakness (UMN degeneration) Movement disorders- tremors, dystonia, chorea 1 PNS : degeneration of large sensory cells in dorsal root ganglion Sensory neuropathy [pedclerk.bsd.uchicago.edu]
Functional basis of ocular motility disorders. Oxford: Pergamon Press 1982: 129–38. 2 Jan JE, Farrell K, Wong PK, McCormick AQ : Eye and head movements of visually impaired children. [nature.com]
Cardiovascular
- Vascular Disease
In this instance it may reflect an underlying mechanism of migraine or cerebro-vascular disease (this is the authors opinion). Leigh RJ, Zee DS. (1991) The neurology of eye movement (2nd Edn), FA Davis (Philadelpha). Yee, R. D. (1989). [tchain.com]
While this most commonly occurs with multiple sclerosis and vascular disease, it also occurs with some metabolic processes, such as abetalipoproteinemia (773). [neuroophthalmology.ca]
Neurologic
- Nystagmus
See Caloric nystagmus, Irritative nystagmus, Paralytic nystagmus, Recovery nystagmus, Opticokinetic nystagmus, Seesaw nystagmus. nys·tag·mus ( nis-tag'mŭs ) Rhythmic oscillation of the eyeballs, either pendular or jerky. [medical-dictionary.thefreedictionary.com]
If the nystagmus is horizontal, the eye movement is usually "to-and-fro". [disorders.eyes.arizona.edu]
Our present understanding of the genetics of hereditary nystagmus is somewhat limited. Few published medical sources have documented the existence of true cases of sex-linked hereditary nystagmus. [ncbi.nlm.nih.gov]
Although the nystagmus frequency was also gaze-angle dependent, it was equal in both eyes. In the null region both nystagmus amplitude and frequency were minimal and equal for the two eyes. [journals.lww.com]
- Pendular Nystagmus
Associated with congenital blindness. optokinetic nystagmus nystagmus induced by looking at objects moving across the field of vision. oscillatory nystagmus pendular nystagmus. pendular nystagmus that which consists of to-and-fro movements of equal velocity [medical-dictionary.thefreedictionary.com]
SPONTANEOUS NYSTAGMUS Vestibular imbalance nystagmus Acquired pendular nystagmus Horizontal Vertical See-saw Congenital Nystagmus Latent nystagmus (LN) Pendular type Jerk type Convergence/Retraction nystagmus Divergence nystagmus Periodic alternating [tchain.com]
Identifier 163-9-4 Title Familial Nystagmus Ocular Movements Congenital Nystagmus; Horizontal Pendular Nystagmus; Infantile Nystagmus Syndrome; Familial Congenital Nystagmus Creator Shirley H. [collections.lib.utah.edu]
Dissociation is common with pendular nystagmus. Acquired pendular nystagmus is dysconjugate in both size and direction in half of cases (Video “acquired pendular nystagmus” ). [neuroophthalmology.ca]
An acquired pendular nystagmus can occur in any plane; it can be monocular or have a greater intensity in one eye and typically remains pendular in all directions of gaze. [ncbi.nlm.nih.gov]
- Myoclonus
The so-called "ocular myoclonus" associated with the oculo-palatal myoclonus syndrome, may respond to valproic acid (Lefkowitz and Harpold, 1985). [tchain.com]
MRI in symptomatic oculopalatal myoclonus shows increased signal in the region of the inferior olive (1217,1221,1222,1226) (Video “oculopalatal myoclonus” ). [neuroophthalmology.ca]
Treatment of ocular myoclonus with valproic acid, Ann Neurol 17:103-104, 1985. [webeye.ophth.uiowa.edu]
It is associated with a wide range of brainstem and cerebellar disease including several disorders of myelin, with the syndrome of oculopalatal myoclonus, with Wipple's disease and with drug toxicities. [ncbi.nlm.nih.gov]
[…] persons with a blood alcohol level between 0.04–0.08 is supported by peer reviewed studies and has been found to be a more accurate indication of blood alcohol content than other standard field sobriety tests. [39] See also [ edit ] Bruns nystagmus Myoclonus [en.wikipedia.org]
- Irritability
See Caloric nystagmus, Irritative nystagmus, Paralytic nystagmus, Recovery nystagmus, Opticokinetic nystagmus, Seesaw nystagmus. nys·tag·mus ( nis-tag'mŭs ) Rhythmic oscillation of the eyeballs, either pendular or jerky. [medical-dictionary.thefreedictionary.com]
Not rubbing the eyes and avoiding such irritants as tobacco smoke can also help persons with dry eye syndrome. [afb.org]
The most common are a transient migratory polyarthralgia, sometimes with true arthritis, abdominal pain, weight loss and a malabsorptive type of diarrhea, often misdiagnosed as irritable bowel syndrome (1248,1260). [neuroophthalmology.ca]
Workup
This innovative one-page format provides the definition, differential diagnosis, workup and diagnosis, and treatment options for nearly 170 diseases and disorders. [books.google.com]
It is accepted as neurologically benign, however, in cases with associated systemic and neurological problems and in cases that is diagnosed after 6 months neuroradiological evaluation and systemic workup are required. [omicsonline.org]
Treatment
Treatment Treatment Options: Congenital nystagmus cannot be cured. However, several treatments may be beneficial. Glasses and contact lenses, and, occasionally, extraocular muscle surgery may be helpful. [disorders.eyes.arizona.edu]
What treatments are available for Nystagmus? Unfortunately, there are not many good treatments for nystagmus. For some specific types, medicines can help and surgery can be used to improve certain features, but for most, little treatment exists. [rnib.org.uk]
Current treatments, such as prism glasses, acupuncture, electronic nerve stimulation, contact lenses, various drug treatments, and others have had limited success. [clinicaltrials.gov]
At present, there is no treatment for this condition. [afb.org]
Prognosis
Prognosis - there is no progression. [patient.info]
Diagnosis and Prognosis: Pediatricians and ophthalmologists are likely to make this diagnosis. It is important that complete physical and neurological examinations are done to rule out other conditions with which nystagmus is associated. [disorders.eyes.arizona.edu]
Prognosis - Hereditary paroxysmal cerebral ataxia Not supplied. Treatment - Hereditary paroxysmal cerebral ataxia Not supplied. Resources - Hereditary paroxysmal cerebral ataxia Not supplied. [checkorphan.org]
Hereditary motor and sensory neuropathy: Roussy-Levy variant Carlevoix-Saguenay - early childhood onset of cerebellar ataxia, pyramidal tract signs, and peripheral neuropathy Infantile onset spinocerebellar ataxia- ataxia, opthalmoplegia, hearing loss Prognosis [pedclerk.bsd.uchicago.edu]
Etiology
Nystagmus can be physiologic or pathologic according to etiology. [omicsonline.org]
Eye injuries in childhood: demography, etiology, and prevention. Pediatrics. 1989;84:438–41. Copyright © 2001 by the American Academy of Family Physicians. This content is owned by the AAFP. [aafp.org]
Etiology Congenital Disease/Diagnosis Familial Infantile Nystagmus Syndrome Treatment Surgical procedures for congenital nystagmus are discussed in ref 8 References 1.. [collections.lib.utah.edu]
This is in contrast to other etiologies of congenital corneal clouding like Peter’s anomaly or a limbal dermoid, which can vary in size/location and often obscure underlying iris. [reviewofophthalmology.com]
The findings established several forms of spinal cord syrinxes with different etiologies and pathogenesis. Levine (2004) proposed a novel theory of the pathogenesis of syringomyelia associated with lesions at the foramen magnum. [genome.jp]
Epidemiology
Congenital eye malformations: clinical-epidemiological analysis of 1,124,654 consecutive births in Spain. Am J Med Genet 1998;75:497-504. 4. Al-Ghamdi A, Al-Rajhi A, Wagoner MD. [reviewofophthalmology.com]
Treatment consist of learning compensatory strategies to take over for the impaired system. [ citation needed ] Epidemiology [ edit ] Nystagmus is a relatively common clinical condition, affecting one in several thousand people. [en.wikipedia.org]
Pathophysiology
Research over the past three decades has led to better understanding of the pathophysiology of acquired forms of nystagmus, suggesting drug therapies. [ncbi.nlm.nih.gov]
While this distinction may be conceptually correct, it does not always reflect the underlying pathophysiology. [aao.org]
Nystagmus Pathophysiology of Nystagmus An article on nystagmus Learning Objectives: to discuss the relationship between eye movements and clear vision. to understand three mechanisms that normally hold gaze steady: visual fixation, the vestibulo-ocular [lowvision.org]
Acquired pendular nystagmus: its characteristics, localizing value, and pathophysiology. J. Neurol Neurosurg Psych 1982:45:431-439 Stahl JS, Rottach KG, Averbuch-Heller L, Maydell RD, Collins SD, Leigh RJ. [tchain.com]
The pathophysiology is a result of inadequate endothelium, and treatment therefore requires replacing the endothelium. [reviewofophthalmology.com]
Prevention
Appropriate eye muscle surgery may be indicated when a significant head deviation is present to prevent secondary changes in neck muscles that may not be correctable later. [disorders.eyes.arizona.edu]
Causes - Hereditary paroxysmal cerebral ataxia * Dizziness * Dysarthria * Impaired balance * Incoordination * Migraine * Nystagmus * Slurred speech * Unsteadiness * Vertigo * Visual disturbance Prevention - Hereditary paroxysmal cerebral ataxia Not supplied [checkorphan.org]
Transplantation Substance Use and Addiction Surgery Surgical Innovation Surgical Pearls Teachable Moment Technology and Finance The Rational Clinical Examination Tobacco and e-Cigarettes Toxicology Trauma and Injury Treatment Adherence United States Preventive [jamanetwork.com]
Low Vision specialists also use special testing techniques during the refraction to measure the eyeglass prescription and prevent inaccurate results from latent nystagmus. [lowvision.org]
It is the leading cause of preventable blindness worldwide. [tsbvi.edu]