In the present study, eight candidate miRNAs, the functions of which are associated with myocarditis, were selected and their expression levels were evaluated by reverse transcription-quantitative polymerase chain reaction. miR-146b and miR-214 were found [ncbi.nlm.nih.gov]

[…] fever, reduced general condition Skin/mucosa Maculopapular and partially vesicular rash on the hands and feet Oral ulcers Diagnosis: clinical Treatment: symptomatic Prognosis: almost always self‑limiting Coxsackie B Myocarditis Pleurodynia Clinical presentation [amboss.com]

All presented with atypical features, with most (n=13) resembling eczema herpeticum or chickenpox. Coxsackievirus A6 (CV-A6) was identified in all the typed cases (n=11). [eurosurveillance.org]

• Fatigue

  We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: March 8, 2020 [patientslikeme.com]

  The common symptoms of Coxsackie virus are fever, sore throat, fatigue and loss of appetite. It would be only for two or three days. Then it appears as sores and blisters on the mouth, throat and hands. [diseasespictures.com]

  Is chronic fatigue following pleurodynia common? Any advice would be much appreciated. [forums.netdoctor.co.uk]

  Symptomology and Outcome: Coxsackie B infection is characterized by fever, fatigue, malaise and chest pains. Infection of the heart by a coxsackie B virus can lead to viral myocarditis. [web.stanford.edu]

  There are also possible associations of Coxsackieviruses with post-viral fatigue syndromes, Reye's syndrome and pancreatitis. [patient.info]

• Sore Throat

  Coxsackie viruses are a common cause of sore throats, especially for children, often in spring and summer. Typical symptoms are a fever, and sore throat and tongue in some cases. [familydoctor.co.nz]

  It may also cause diarrhea or a sore throat that is similar to strep throat. There are some more severe syndromes caused by the virus, but these are less common. [emedicinehealth.com]

• Chest Pain

  When to Call Your Pediatrician Call your pediatrician if your child complains of neck pain, chest pain, difficulty breathing, listlessness, or lethargy. [healthychildren.org]

  Pain on inspiration is similar to pleuritic pain and pulmonary embolism may be suspected. The muscles are locally tender. Fever, headache or nonspecific abdominal pain - either as prodromal symptoms or with the onset of chest pain. [patient.info]

  Pleurodynia Pleurodynia is an inflammation of the muscles in the chest. It causes a sudden onset of sharp chest pain which gets worse when taking a deep breath. Pain may also be present in the abdomen. The pain comes and goes in waves or spasms. [emedicinehealth.com]

• Weak Pulse

  On admission weak pulses and lip cyanosis were observed. He was intubated and transferred to our pediatric intensive care unit for further care. On admission his pulse rate was 187 beats/min and his blood pressure was 64/32 mm Hg. [journals.lww.com]

• Left Ventricular Dysfunction

  Myocarditis Coxsackievirus B is one of the more common causes of myocarditis, with potential to progress to dilated cardiomyopathy.[6] Viral myocarditis may be asymptomatic, or may present with symptoms of heart failure and left ventricular dysfunction [patient.info]

• Lip Cyanosis

  On admission weak pulses and lip cyanosis were observed. He was intubated and transferred to our pediatric intensive care unit for further care. On admission his pulse rate was 187 beats/min and his blood pressure was 64/32 mm Hg. [journals.lww.com]

• Headache

  If your granddaughter develops more-serious signs or symptoms, such as severe headaches, joint pain or a high fever, she should be evaluated by a doctor. [mayoclinic.org]

  Stiff neck, headache, and pain related to bright lights (photophobia) are signs of meningitis. [healthychildren.org]

  Others suddenly get a high fever, headache, and muscle aches, and some also develop a sore throat, abdominal discomfort, or nausea. A child with a coxsackievirus infection may simply feel hot but have no other symptoms. [kidshealth.org]

  Headache – Small children often experience headache due to HFMD As will most viral illnesses children with HFMD experience loss of appetite. There is a sore throat. The throat is often painful. [news-medical.net]

• Seizure

  If you experience a rash, fever, seizure, severe headache, stiff neck, shortness of breath, or chest pain, you should seek medical attention to gain a proper diagnosis for your symptoms. [belmarrahealth.com]

  Possible complications that may result from HFMD include: Loss of body fluids (dehydration) Seizures due to high fever (febrile seizures) Call your provider if there are signs of complications, such as pain in the neck or arms and legs. [medlineplus.gov]

  Febrile seizures may occur in children. Seizures are less common in adults, although adults may complain of fatigue that lasts for weeks after the meningitis resolves. [emedicinehealth.com]

• Grunting

  The second case involved a 7-month-old boy with grunting and tongue ulcers. 4 The patient died 4 days after onset of clinical manifestations of irritability, respiratory distress, tachycardia, cyanosis and convulsion. [journals.lww.com]

Laboratory workup revealed segmented neutrophil predominant leukocytosis, elevated levels of troponin (2.45 ng/ml), BNP (457.2 pg/ml), and d-dimer (6.72 µg/ml). [hindawi.com]

[…] infection with AIDS-defining opportunistic infections These 3 categories are further subdivided on the basis of the CD4+ T-cell count, as follows: > 500/µL: Categories A1, B1, C1 200-400/µL: Categories A2, B2, C2 < 200/µL: Categories A3, B3, C3 See Workup [emedicine.medscape.com]

• Hypertriglyceridemia

  DISCUSSION Acute pancreatitis may have diverse etiologies such as alcohol ingestion (acute or chronic), gallstones, drugs and toxins, metabolic disorders (hypertriglyceridemia, hypercalcaemia, and others), connective tissue diseases, infections, and others [pancreas.imedpub.com]

However, this treatment strategy has to be evaluated in vivo to develop a new treatment strategy for patients suffering with viral myocarditis. [ncbi.nlm.nih.gov]

Diagnostic procedures and treatment should be tailored to the specific disease manifestation. [amboss.com]

The viral infection is usually self-limited and no treatment is necessary. However, it is highly contagious and preventing transmission is hard. [patientslikeme.com]

Coxsackievirus Treatment : No particular treatment is available for Coxsackie virus infection. However based on the symptoms and its intensity the doctor may recommend Tylenol for reducing the discomfort of fever. [diseasespictures.com]

The prognosis of HFMD is excellent, with the vast majority resolving spontaneously in 5-10 days. [patient.info]

Thus, the effects of a relatively common infection during the neonatal period may be long lasting, and the prognosis for newborn infants recovering from acute infection should be reexplored. [ncbi.nlm.nih.gov]

Prognosis Prognosis of mild congenital EV infections is quite good if reanimation procedures are available. Prognosis of severe congenital EV infections is poor and the disease has been reported to be fatal. [orpha.net]

[…] mouth disease Characteristics: highly contagious Clinical presentation General symptoms: fever, reduced general condition Skin/mucosa Maculopapular and partially vesicular rash on the hands and feet Oral ulcers Diagnosis: clinical Treatment: symptomatic Prognosis [amboss.com]

References:[2][3][4] Coxsackie virus infections Summary Epidemiology Etiology Disease manifestations [amboss.com]

Abstract Recently, it has been suggested that coxsackievirus plays an etiologic role in juvenile dermatomyositis (DM). [ncbi.nlm.nih.gov]

The incidence of pancreatitis of unknown etiology may even be higher since the diagnosis of acute pancreatitis can be difficult and may go undetected. [pancreas.imedpub.com]

Epidemiology Worldwide distribution Occur in all age groups Highest incidence in infants and young children (< 10 years) References:[1] Epidemiological data refers to the US, unless otherwise specified. [amboss.com]

The epidemiology and pathogenicity of SAFV remain unclear. METHODS: Between July 2009 and October 2010, nasopharyngeal specimens were collected from children with acute respiratory infections. [ncbi.nlm.nih.gov]

Abstract | Full Text The report is an overview of enterovirus epidemiology in Piemonte during a 5-year period from 2000 to 2004 with an investigative protocol recording epidemiologic, clinical, and laboratory data. [doaj.org]

Epidemiology and control of hand, foot and mouth disease in Singapore, 2001-2007. Ann Acad Med Singapore. 2009 Feb. 38(2):106-12. [Medline]. Bergman I, Painter MJ, Wald ER, et al. [emedicine.medscape.com]

We have recently reported the possible role of the cysteine‐rich secretory protein 3 gene (a member of the latter group of differentially expressed genes) (5) in the pathophysiology of primary SS. [onlinelibrary.wiley.com]

Pathophysiology of Coxsackie's virus <ul><li>Coxsackieviruses are transmitted primarily via the fecal -oral route and respiratory aerosols, although transmission via fomites is possible. [slideshare.net]

Pathophysiology Coxsackieviruses are transmitted primarily via the fecal-oral route and respiratory aerosols, although transmission via fomites is possible. The viruses initially replicate in the upper respiratory tract and the distal small bowel. [emedicine.medscape.com]

Centers for Disease Control and Prevention. "Hand, Foot, and Mouth Disease." Dec. 22, 2017. <http://www.cdc.gov/hand-foot-mouth/about/index.html>. United States. Centers for Disease Control and Prevention. [medicinenet.com]

Two weeks before the outbreak of the lesions, the patient had suffered from a viral pharyngitis, subsequently diagnosed as herpangina, and had been taking an oral cephalosporin (cefixime) for 1 week to prevent possible bacterial complications. [ncbi.nlm.nih.gov]