Presentation
Past Infection If antibodies to both the viral capsid antigen and EBNA are present, then past infection (from to 6 months to years earlier) is indicated. [phoenixrising.me]
[…] in his childhood due to idiopathic thrombocytopenic purpura (ITP) presented with jaundice and dark urine. [austinpublishinggroup.com]
Consistent with this finding, a diagnosis of HPS was significantly delayed in the present case because of the clinical presentation. [journals.lww.com]
// Annals of Internal Medicine;May87, Vol. 106 Issue 5, p775 A letter to the editor and a reply are presented in response to the article "Chronic Epstein-Barr virus infection associated with fever and interstitial pneumonitis: clinical and serologic [connection.ebscohost.com]
Case presentation We describe the case of an elderly immunocompetent female who presented with non-specific symptomatology, lymphadenopathy, cytopenias, elevated autoantibody titers and a crescent EBV viral load that were suggestive of a multisystemic [bmchematol.biomedcentral.com]
Entire Body System
- Fatigue
There was no greater fatigue at onset or after 6 months in either cohort, but those who complained of fatigue at 6 months were more likely to have had fatigue at onset and psychological distress before presentation. [healio.com]
Abstract Twenty-three patients with polymyalgia rheumatica (PMR) followed in an academic rheumatology practice frequently reported symptoms commonly found in the recently described "chronic fatigue syndrome" or "chronic Epstein-Barr infection syndrome [unboundmedicine.com]
Detailed immunologic, neurologic, endocrinologic, and psychologic studies are being conducted on selected patients with chronic fatigue. [grantome.com]
The patient developed chronic fatigue and chronic renal failure with a serological profile typical of primary EBV infection. Clinical improvement with anti-EBNA seroconversion occurred after acyclovir therapy. [prohealth.com]
- Chronic Fatigue Syndrome
Since CRH induces CNS arousal, these neuroendocrine findings suggest a new mechanism whereby the lethargy of Chronic Fatigue Syndrome patients may be explained. [grantome.com]
Chronic Fatigue Syndrome. N.Y. Wiley 1993; pp. 83-101. 3. Jason LA, Richman JA, Rademaker AW, et al. A community-based study of chronic fatigue syndrome. Arch Intern Med. 1999;159:2129-2137. 4. Dowsett EG, Colby J. [healio.com]
Abstract Twenty-three patients with polymyalgia rheumatica (PMR) followed in an academic rheumatology practice frequently reported symptoms commonly found in the recently described "chronic fatigue syndrome" or "chronic Epstein-Barr infection syndrome [unboundmedicine.com]
The CDC believes EBV reactivation plays no role in chronic fatigue syndrome. [phoenixrising.me]
- Intermittent Fever
Abstract: Chronic active Epstein-Barr virus infection (CAEBV) is characterized mainly by prolonged or intermittent fever, lymphadenopathy and hepatosplenomegaly without definite underlying diseases at the diagnosis. [eurekaselect.com]
An 18-year-old girl was admitted to our hospital with a history of edema in the lower limbs and intermittent fever lasting for more than 1 month. At admission, she had severe liver injury of unknown etiology. [journals.lww.com]
Respiratoric
- Sputum
Blood and sputum culture results remained negative. Serological test results confirmed a past EBV infection and were negative for a wide range of other acute viral infections. [academic.oup.com]
Workup
Further infectious workup from a nasopharyngeal swab was positive for rhinovirus detected by PCR. [austinpublishinggroup.com]
Infectious Mononucleosis Workup. Medscape. Available online at http://emedicine.medscape.com/article/222040-workup. Accessed June 13, 2016. (Aug 2004) Hess, R. [labtestsonline.it]
Splenomegaly of 10.76 cm was found incidentally during workup. [scielo.org.mx]
Treatment
Fifty days after the start of treatment, the patient developed respiratory insufficiency, treatment refractory hypotension, gastrointestinal hemorrhages, and renal failure. EBV load had increased to 3.5×10 6 copies/mL. [academic.oup.com]
Expanded Access : Baylor College of Medicine has indicated that access to an investigational treatment associated with this study is available outside the clinical trial. [clinicaltrials.gov]
You can help by adding to it. ( February 2019 ) Treatment [ edit ] The only known cure for CAEBV is allogenic haematopoietic stem cell transplant (HSCT), with all other treatment options ( rituximab, cytotoxic chemotherapy and immunosuppressive therapy [en.wikipedia.org]
The ultimate prognosis of CAEBV is very poor and to date there are no established treatment strategies for this disorder. [nature.com]
To maximize survival rates with minimized late sequelae, we recommend earlier initiation and completion of the 3-step treatment without watchful waiting. [pubfacts.com]
Prognosis
Prognosis - Chronic Active Epstein Barr Virus Infection Not supplied. Treatment - Chronic Active Epstein Barr Virus Infection Not supplied. Resources - Chronic Active Epstein Barr Virus Infection Not supplied. [checkorphan.org]
Epileptic Spasms After Stem Cell Transplantation for Chronic Epstein-Barr Virus Infection Stem cell transplantation has been performed for various diseases, contributing to a markedly improved prognosis in some cases. [drcalapai.net]
[ edit ] Without HSCT the condition is inevitably fatal and even HSCT is no guarantee, with a significant portion of patients dying from the disease progression. [8] Factors indicative of a poor prognosis include: thrombocytopenia, late onset of the [en.wikipedia.org]
The majority of people with EBV have a good prognosis; a few have a more guarded prognosis. There is no vaccine for EBV, and prevention is difficult. [medicinenet.com]
Acquired HPS is a hyperinflammatory syndrome associated with a variety of underlying conditions such as severe infectious diseases, autoimmune diseases, malignancies, and acquired immune deficiency syndrome. [8] The prognosis of adult patients with HPS [journals.lww.com]
Etiology
An etiologic relation between Epstein-Barr virus replication and the clinical manifestations of this syndrome is further shown by the response of each patient to acyclovir therapy. [annals.org]
In adolescents older than 12 years, the prevalence of CFS was almost 0.15%.5 The etiology of CFS is unknown. Many patients recall a viral infection that seems to have triggered their chronic fatigue. [healio.com]
Intracranial aneurysm etiologies include atherosclerosis, hypertension, vasculopathy, trauma, drug abuse, neoplasm, and infection. [ajnr.org]
Occult malignancies are also etiologies of such a clinical presentation, especially in elderly population [ 6 – 8 ]. [bmchematol.biomedcentral.com]
Hooks JJ: Possibility of a viral etiology in recurrent aphthous ulcers and Behçet's syndrome. J Oral Pathol 1978;7:353-364. [karger.com]
Epidemiology
Epidemiology EBV is a ubiquitous, worldwide pathogen that is harbored persistently by virtually all adults, regardless of geographic location. [pedsinreview.aappublications.org]
the Departments of Pediatrics and Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn.; and the Pathology Department, Stanford University School of Medicine, Palo Alto, Calif. Address reprint requests to Dr. [nejm.org]
However, changes in economic status may have changed both the age of initial infection and the incidence of infectious mononucleosis since the large epidemiologic studies were completed. [emedicine.medscape.com]
The changing epidemiology of infectious mononucleosis? J Infect. 2002;45(2):107-9. [hopkinsguides.com]
Epidemiology of chronic fatigue syndrome: The Centers for Disease Control study. In: Bock G, Whelan J, eds. Chronic Fatigue Syndrome. N.Y. Wiley 1993; pp. 83-101. 3. Jason LA, Richman JA, Rademaker AW, et al. [healio.com]
Pathophysiology
EBV+ LPD ). [2] Presentation [ edit ] The most common symptoms of CAEBV include: [1] [3] [4] [5] Complications include: [1] [3] [5] Pathophysiology [ edit ] It arises from the cells that constitute the immune system, most often the T-cells and NK cells [en.wikipedia.org]
Studying adolescents following EBV infection undoubtedly will prove important for delineating the pathophysiology of both infectious mononucleosis and CFS. [healio.com]
The pathophysiological mechanism of these features that mimic liver failure is related to macrophages activated by high levels of cytokines, which are secreted by proliferating T lymphocytes. [journals.lww.com]
Prevention
China Yi Zeng, Cangwu Institute for Nasopharyngeal Carcinoma Control and Prevention - China Stephen J. [nsuworks.nova.edu]
Prevention - Chronic Active Epstein Barr Virus Infection Not supplied. Diagnosis - Chronic Active Epstein Barr Virus Infection Not supplied. Prognosis - Chronic Active Epstein Barr Virus Infection Not supplied. [checkorphan.org]
This list is a group of supplements that inhibit Th1 but also prevent its reactivation. I plan on creating a list of EBV inhibitors that also increase Th1 cells. To prevent EBV reactivation you want to take Th1 supplements instead. [selfhacked.com]
Is it possible to prevent an Epstein-Barr virus infection? Is there an EBV vaccine? There is no vaccine available to prevent EBV infections. [medicinenet.com]
Causes According to the Centers for Disease Control and Prevention (CDC), the most common cause of mono is the Epstein-Barr virus (EBV), which is found all over the world and infects the majority of the human population at some point in their lives. [livescience.com]