Primary bilateral non-Hodgkin's lymphoma of the adrenal gland is a rare presentation with <200 reported cases. [ncbi.nlm.nih.gov]

• Anemia

  Despite identified limitations in the grading and reporting of treatment-related anemia, the results confirm a relatively high incidence of mild-to-moderate anemia. [ncbi.nlm.nih.gov]

  A low red blood cell count is known as anemia. Anemia can lead to fatigue, chest pain, and more serious complications. Platelets are structures in the blood that help stop bleeding. A low platelet cell count is known as thrombocytopenia. [chemotherapy.com]

  The purpose of the guidelines is to operationalize the evaluation and treatment of anemia in cancer patients and to enable patients and clinicians to evaluate treatment options in the context of risks and benefits. [doi.org]

• Hodgkin Lymphoma

  Primary bilateral non-Hodgkin's lymphoma of the adrenal gland is a rare presentation with <200 reported cases. [ncbi.nlm.nih.gov]

  Other tumours reported at increased incidence, in particular among Hodgkin's disease patients, for whom a carcinogenic effect of chemotherapy seems plausible, are non-Hodgkin's lymphoma and lung cancer. [informahealthcare.com]

• Malaise

  A low red blood cell count (anemia) causes fatigue, paleness, dizziness, shortness of breath and malaise. Fatigue Fatigue makes a person feel more tired than usual and can interfere with daily activities and sleep. [cancer.ca]

  In the elderly, symptoms of cholecystitis may be nonspecific (eg, anorexia, vomiting, malaise, weakness), and fever may be absent. [msdmanuals.com]

• Refractory Anemia

  DIAGNOSES: The patient was diagnosed with MDS refractory anemia with excess of blast II and was classified as very high risk according to the revised international prognostic scoring system. [ncbi.nlm.nih.gov]

• Loss of Appetite

  Chemotherapy commonly causes nausea, vomiting, loss of appetite, weight loss, fatigue, and low blood cell counts that lead to anemia and increased risk of infections. [merckmanuals.com]

  Other side effects of docetaxel include low platelets which can result in bleeding (1%), anemia (5%), reduced heart function (10%), hair loss (65%), diarrhea (32%), nail changes (30%), loss of appetite (20%), shortness of breath (15%), and fluid retention [pcf.org]

  Some common side effects of chemotherapy that can occur in the days or weeks after treatment include: fatigue (tiredness) nausea, vomiting and loss of appetite pain or soreness, such as headaches, muscle pain or nerve pain sores in the throat or mouth [canceraustralia.gov.au]

  After treatment with chemotherapy, you may lose your hair and have other side effects, such as loss of appetite, nausea, vomiting, diarrhea, or mouth sores. [northshore.org]

  Possible Side Effects Side effects of chemotherapy can include: Nausea Vomiting Loss of appetite Malnutrition Hair loss Bleeding or damage to the heart, liver or kidneys Chemotherapy can weaken the body's immune system. [cedars-sinai.edu]

• Sore Mouth

  Sore mouth A sore mouth (also called stomatitis or oral mucositis) happens because of chemotherapy’s effect on cells inside the mouth. Many drugs can cause a sore mouth, but it happens more often when higher doses of drugs are used. [cancer.ca]

  This can cause a range of unpleasant side effects, such as: feeling tired most of the time feeling sick and vomiting hair loss an increased risk of picking up infections a sore mouth dry, sore or itchy skin diarrhoea or constipation Many of these side [nhs.uk]

  If you have a sore mouth and are not eating properly, chilled drinks such as smoothies from the blender can be good. Early menopause Chemotherapy can reduce your oestrogen levels and cause periods to stop, either temporarily or altogether. [bcna.org.au]

  Mouth sores: Mouth sores, also referred to as mucositis, are caused by an inflammatory reaction of the mucous lining of the gastrointestinal tract. They can also affect chewing, swallowing and taste, and can be managed with pain medication. [mesothelioma.com]

• Metallic Taste

  Eating soft mints can help get rid of the metallic taste that you may experience. If you have a sore mouth and are not eating properly, chilled drinks such as smoothies from the blender can be good. [bcna.org.au]

  You might even have a metallic taste in the mouth, or a yellow or white coating on your tongue. Food may taste unusual or unpleasant, leading to unintentional weight loss from not eating. [healthline.com]

  Changes in taste and smell Some chemotherapy drugs can affect taste buds causing changes in taste. For example, you may find that meats have a metallic taste. Even foods that you normally crave, such as sweet or salty snacks, can taste bad. [cancer.ca]

  Changes in taste – many people say food tastes bland. Others describe a metallic taste, or find that food tastes more salty or bitter than usual. Skin changes including rashes – some drugs make your skin photosensitive (more sensitive to sunlight). [lymphoma-action.org.uk]

• Alopecia

  There were no differences between men and women with regard to body image in respect of degree of alopecia, but the body image of the male and female patients who had partial or complete alopecia was lower than that in patients who had no alopecia; psychological [ncbi.nlm.nih.gov]

  Few dermatologic conditions carry as much emotional distress as chemotherapy-induced alopecia (CIA). The prerequisite for successful development of strategies for CIA prevention is the understanding of the pathobiology of CIA. [doi.org]

  When side effects of chemotherapy do occur, here are some of the most common: Anemia Appetite Changes Bleeding Problems Constipation Diarrhea Fatigue (Feeling weak and very tired) Hair Loss (Alopecia) Infection Memory Changes Mouth and Throat Changes [virtua.org]

  Hair follicles have cells that can be affected by chemo, leading to hair loss, also called alopecia. Cells lining your stomach can also be affected by chemo. This can cause vomiting and diarrhea, and may be associated with nausea. [chemotherapy.com]

• Amenorrhea

  After ABVD or 4–6 cycles of CHOP the risk of permanent amenorrhea has been reported to be below 20% [11] Lee SJ, Schover LR, Partridge AH, Patrizio P, Wallace WH, Hagerty K, et al. [doi.org]

  Two FSH levels in the menopausal range measured at least one month apart and associated with amenorrhea/oligomenorrhea and low estradiol levels are strongly suggestive of ovarian failure. [medscape.com]

  Disease Regimen % Low Sperm Count Hodgkin's MOPP 85% Hodgkin's ABVD 0 Testes Cancer Cisplatin, vinblastine, bleomycin 14-28% Sarcoma Doxorubicin + Cyclophosphamide 65% Disease Regimen % Amenorrhea Ovarian Cancer Cisplatin, Vincristine, methotrexate, etoposide [cancersupportivecare.com]

  […] particularly in males) an alteration of reproductive functions, with: azoospermia (frequency up to 100% of cases, sometimes reversible after therapy termination; it imposes a beforehand semen collection and preservation in young patients); secondary amenorrhea [medichub.ro]

• Secondary Amenorrhea

  amenorrhea (it occurs at 3-4 months after the chemotherapy; recovery is variable and it depends on the age when the cytostatic treatment was started – in young women it can reach over 50% of cases). [medichub.ro]

  Secondary amenorrhea after Hodgkin's lymphoma is influenced by age at treatment, stage of disease, chemotherapy regimen, and the use of oral contraceptives during therapy: A report from the German Hodgkin's Lymphoma Study Group. [doi.org]

[…] acute cholecystitis MRI without contrast is useful for eliminating radiation exposure in pregnant women when ultrasonography has not yielded a clear diagnosis Contrast agents should not be used in patients on dialysis unless absolutely necessary See Workup [emedicine.medscape.com]

This study changed the workup of all people with advanced gastric cancer since all people with advanced gastric cancer must now undergo HER‐2 testing before the initiation of any chemotherapy and, in the absence of contraindications, be treated with trastuzumab [doi.org]

One patient underwent a re-biopsy after chemotherapy and nivolumab treatment, and the other two cases underwent a re-biopsy after chemotherapy, radiotherapy and nivolumab treatment. [ncbi.nlm.nih.gov]

Reduced drug sensitivity may cause the failure of chemotherapy and affect the prognosis of patients with cancer. [ncbi.nlm.nih.gov]

Laboratory and instrumental examinations performed did not suggest any specific etiology. After 15 days of medical support, the patient presented a complete cardiac function and clinical recovery. [ncbi.nlm.nih.gov]

Epidemiology Common in uncircumcised newborns or uncircumcised men with poor hygiene and accumulation of smegma May be due to poor hygiene, sexual transmission or associated with dermatologic disorders Etiology Due to propensity of pathogenic bacteria [pathologyoutlines.com]

Mesothelioma in the United States: a Surveillance, Epidemiology, and End Results (SEER)–Medicare investigation of treatment patterns and overall survival. [asbestos.com]

Browse issues Year Issue Browse by volume Browse supplements Volume 72, Issue 8 August 2017 Cover image Cover image ISSN 0305-7453 EISSN 1460-2091 Issue navigation Reviews Original research Research letters Next > Reviews Editor's Choice Global epidemiology [academic.oup.com]

Epidemiology Common in uncircumcised newborns or uncircumcised men with poor hygiene and accumulation of smegma May be due to poor hygiene, sexual transmission or associated with dermatologic disorders Etiology Due to propensity of pathogenic bacteria [pathologyoutlines.com]

Credit: The journal Pain There have been no epidemiologic studies to determine what percentage of chemotherapy patients is affected. [doi.org]

CONCLUSIONS: This rare event stresses our inability to correctly predict the risk of a patient developing cardiotoxicity and also highlights the need to improve the knowledge of underlying pathophysiological mechanisms; in fact, it suggests a possible [ncbi.nlm.nih.gov]

Internal Medicine (55) Medical Chemistry and Biochemistry (54) Pathology and Forensic Medicine (54) Physiology and Pathophysiology (49) Paediatrics, Neonatology (46) Gastroenterology and Hepatology (34) Surgery, Traumatology and Orthopaedics (32) Infectology [portal.mefanet.cz]

Malnutrition and cachexia in ovarian cancer patients: pathophysiology and management. Anticancer Res. 2001;21(4B):2941–2947. Google Scholar 15. Garcia-Luna PP, Parejo Campos J, Pereira Cunill JL. [doi.org]

Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 65. Updated by: Michael M. [medlineplus.gov]

Abstract BSTRACT Introduction: The aim of this study was to investigate the potential role of melatonin in the prevention of chemotherapy-induced nephrotoxicity at the preclinical level. [ncbi.nlm.nih.gov]

If a preventive treatment is discovered, “you're not only preventing a condition that can cause months or even years of suffering, but it's the pain and the neuropathy that is limiting the dose of these drugs,” Bennett said. [doi.org]