The patient presented with left hip pain 3 years later. Radiography and computed tomography demonstrated osteosclerosis of the left proximal femur, and MRI revealed an intramedullary metastatic lesion. [ncbi.nlm.nih.gov]

• Weakness

  A 28-year-old man with history of anaplastic oligodendroglimoma in the left frontal lobe presented with worsening right leg weakness 2 months after surgical resection. [ncbi.nlm.nih.gov]

  Cancers that are located in the frontal lobe may cause weakness on one side of the body, personality or behavior changes, and difficulty with short- term memory. [secure.ssa.gov]

  If they are in the frontal lobe this may cause gradual changes in mood and personality, weakness or numbness in muscles of one side of the body. [thebraintumourcharity.org]

• Pain

  The patient was started on standard temozolomide chemotherapy and celecoxib with prompt pain relief, and rapid normalization of serum alkaline phosphatase. [ncbi.nlm.nih.gov]

• Pathologist

  The panel reached consensus on the diagnosis of AOD in 52% of the tumors that had been diagnosed as AOD by the local pathologists, whereas only 8% of the local diagnosis of AOA was confirmed with consensus. [ncbi.nlm.nih.gov]

  The unique molecular features and chemosensitivity of the oligodendroglioma were not appreciated 10 years ago; yet today, these features merit such interest to clinicians and pathologists alike that the oligodendroglioma is separated from other types [jamanetwork.com]

  Department of Pathology and Immunology, Baylor College of Medicine Adekunle M Adesina, MD, PhD is a member of the following medical societies: American Association for the Advancement of Science, American Association of Neuropathologists, College of American Pathologists [emedicine.medscape.com]

  Histopathological-molecular genetic correlations in referral pathologist-diagnosed low-grade “oligodendroglioma.” J Neuropathol Exp Neurol. 2002 ; 61 : 58 -63. 11 Giannini C, Scheithauer BW, Weaver AL, et al. [academic.oup.com]

• Nausea

  The longitudinal analysis showed a significant increase in nausea/vomiting in the RT plus PCV chemotherapy arm during and shortly after chemotherapy. [ncbi.nlm.nih.gov]

  […] treated with TMZ, whether used in combination with RT or as monotherapy following RT for newly-diagnosed glioblastoma multiforme, or as monotherapy in patients with recurrent or progressive glioma, the reported very common adverse reactions were similar: nausea [mymemory.translated.net]

  Other symptoms include headache, nausea and vomiting, ataxia (difficulty with balance), dizziness and altered mental state. [uclahealth.org]

• Hip Pain

  The patient presented with left hip pain 3 years later. Radiography and computed tomography demonstrated osteosclerosis of the left proximal femur, and MRI revealed an intramedullary metastatic lesion. [ncbi.nlm.nih.gov]

• Dyslexia

  Alterations Memory Loss Impaired Vision When it appears in the parietal lobe, it often causes: Disturbances in the sense of touch Problems with balance and coordination Inability to maintain concentration and perception of sensory and visual senses Dyslexia [cancerwall.com]

• Seizure

  Antiseizure medicines are given to prevent seizures. They are usually not given unless the tumour has caused seizures. A commonly used antiseizure drug is phenytoin (Dilantin). [cancer.ca]

• Headache

  Fig. 4 A 21-year-old man who had a long history of headache developed a sudden onset hemiplegia. CT scan shows a left frontal hemorrhage, with evidence of calcifications and edema, suggestive of a hemorrhage in a tumor. [neurologic.theclinics.com]

  A case of anaplastic oligodendroglioma with femoral metastasis is presented in a 37-year old male with a 2-year history of progressive headaches and dizziness associated with a 2-month history of epilepsy and right hemiparesis. [ncbi.nlm.nih.gov]

• Personality Change

  The most common symptoms are seizures, headaches, and personality changes. Other symptoms vary by location and size of the tumor. [abta.org]

  Symptoms may include seizures, headaches, and personality changes. Other symptoms may vary depending on the location and size of the tumors including short-term memory loss, visual loss, motor weakness, and language problems. [diseaseinfosearch.org]

• Generalized Seizure

  A 17-year-old woman presented with an anaplastic oligodendroglioma manifesting as generalized seizure. Neuroimaging studies revealed a right frontal tumor. [ncbi.nlm.nih.gov]

  However, the patient didn’t perform any control and presented to our hospital in 2010, July, for a generalized seizure; MRI showed a considerable growth of the previously detected lesion, which presented hyperintense in T2 flair images with some nodular [jneuro.com]

• Papilledema

  The symptoms of increased intracranial pressure, such as headache, visual disturbances, and papilledema, are generally associated with intraventricular lesions. [dovepress.com]

  Among 323 patients from an AFIP series, the most common clinical signs were paralysis (50%), visual loss (49%), papilledema (47%), ataxia (39%), abnormal reflexes (37%), and meningismus (10%) (,6). [pubs.rsna.org]

Structural magnetic resonance imaging (MRI) and histopathologic tissue sampling are routinely performed as part of the diagnostic workup for patients with glioma. [ncbi.nlm.nih.gov]

We hypothesized that chemotherapy would impair HRQOL during treatment but that there would be a similar HRQOL between treatment arms once off treatment. [ncbi.nlm.nih.gov]

Treatment Recommendations The survey asked respondents to indicate their preferred treatment for a patient with a newly diagnosed anaplastic oligodendroglioma, given a variety of genetic scenarios (Table 3). [academic.oup.com]

Prognosis A prognosis is an estimate of the likely progress of a disease after a diagnosis, based on an average patient group. [braintumour.ca]

We found that surgical patients had a better prognosis for OS compared to non-surgical (P = 0.006). Furthermore, multivariate Cox regression analysis demonstrated that surgical patients had a better prognosis for OS, even after PSM. (p<0.001). [journals.plos.org]

The only clinical relevant meaning of this histologic diagnosis was the observation that the prognosis of OD was in general better than that of astrocytic tumors of similar grade. [ncbi.nlm.nih.gov]

Treatment and prognosis Prognosis with maximal surgical and medical management is significantly poorer than WHO grade II oligodendrogliomas but better than anaplastic astrocytomas 1. [radiopaedia.org]

Etiology The etiology is not known but no hereditary forms of oligodendroglioma have been reported. However, specific genetic characteristics, such as loss of chromosomes 1p and 19q, are observed. [orpha.net]

Epstein-Barr virus infection has been implicated in the etiology of primary CNS lymphoma. [cancer.gov]

Document Info Overview Authors Authorship HEATH JA NG J BESHAY V A/PROF Lee Coleman DR Patrick Lo PROF David Amor Has subject area For 2008 4 Digit Code Oncology and Carcinogenesis Paediatrics and Reproductive Medicine For 2008 6 Digit Code Cancer Genetics Epidemiology [findanexpert.unimelb.edu.au]

Author information 1 1] Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK [2] Inserm, U 1127, ICM, F-75013 Paris, France [3] CNRS, UMR 7225, ICM, F-75013 Paris, France [4] Institut du Cerveau et de la [ncbi.nlm.nih.gov]

Epidemiologic data mostly based on previous WHO histologic classifications Incidence rate of 0.11 cases per 100,000 population (Neuro Oncol 2014;Suppl 4:iv1) 0.5% of primary brain tumors, 2.5% of all gliomas Median age at diagnosis of 49 years (approximately [pathologyoutlines.com]

Histology of Oligodendroglioma oligodendroglioma (WHO grade II) anaplastic oligodendroglioma (WHO grade III) Epidemiology of Oligodendroglioma peak age between 35 and 50 in childhood around 10 men are a little more often affected Symptoms of Oligodendroglioma [hirntumorhilfe.org]

Summary Epidemiology Until now, the incidence of these tumors has been largely underestimated. Oligodendrogliomas may represent up to 30% of all adult gliomas. [orpha.net]

Pathophysiology of the seeding of intracranial tumours via the cerebrospinal fluid is reviewed. [ncbi.nlm.nih.gov]

Pathophysiology Oligodendrogliomas arise in the cerebral hemispheres and are distributed among the frontal, parietal, temporal, and occipital lobe, in approximately a 3:2:2:1 ratio. [emedicine.medscape.com]

All of these pathophysiological mechanisms, in addition to many other general factors, such as stasis, the presence of inflammation, dysproteinemia, infections, and entrapment, contribute to the hypercoagulable state. [dovepress.com]

Clinical trials look at new ways to prevent, find and treat cancer. Find out more about clinical trials. [cancer.ca]

This case emphasizes the importance of considering this diagnosis to prevent unnecessary irradiation of such rumours. [ncbi.nlm.nih.gov]

Research is exploring ways to prevent or treat cancer through vaccines. Gene therapy uses viruses or other vectors to introduce new genetic material into tumor cells. [mayfieldclinic.com]