Unresponsiveness: Causes & Reasons

Possible Causes for Unresponsiveness

To investigate the clinical course and early prognostic markers in cardiac arrest (CA) patients discharged from the intensive care unit (ICU) in an unresponsive wakefulness [ncbi.nlm.nih.gov]

AIM: To evaluate the effectiveness and the use of Glasgow Coma Score (GCS) and Full Outline of Unresponsiveness (FOUR) score by nurses in the follow-up and evaluation of patients [ncbi.nlm.nih.gov]

HYPOTHESIS: Bedside and remote assessments of patients with decreased LOC, using either the Glasgow Coma Scale (GCS) or Full scale Of UnResponsiveness (FOUR), score are equivalent [ncbi.nlm.nih.gov]

Conversion Disorder

She was first evaluated for causes of her stridor and unresponsiveness. [ncbi.nlm.nih.gov]

Upon admission to the hospital, he developed syncopal-like episodes of unresponsiveness associated with body-wide jerking and stiffening as well as tachycardia and hypertension [ncbi.nlm.nih.gov]

For example, patients may present with impaired coordination or balance, weakness, paralysis of an arm or a leg, loss of sensation in a body part, seizures, unresponsiveness [merckmanuals.com]

Aquagenic Epilepsy

The seizures consisted of staring, oral automatisms, and unresponsiveness, followed in rare occasions by brief tonic posturing of upper extremities, perioral cyanosis, and [ncbi.nlm.nih.gov]

[…] seizures can occur in response to bathing if it is distressing and can be difficult to distinguish clinically from water reflex epilepsy as both can cause hypotonia, apnea, unresponsiveness [ncbi.nlm.nih.gov]

It can present as an episode of altered or loss of consciousness accompanied by staring gaze, pallor, unresponsiveness and postictal somnolence. [dergipark.org.tr]

Meningitis

[…] bright lights being very sleepy or difficult to wake fits (seizures) Babies may also: refuse feeds be irritable have a high-pitched cry have a stiff body or be floppy or unresponsive [nhs.uk]

[…] above being sick a headache a rash that does not fade when a glass is rolled over it (but this will not always develop) a stiff neck a dislike of bright lights drowsiness or unresponsiveness [nhs.uk]

[…] hands and feet (Image: meningitisnow.org) Refusing food and vomiting (Image: meningitisnow.org) Fretful, dislike being handled (Image: meningitisnow.org) Drowsy, floppy, unresponsive [dublinlive.ie]

Metabolic Encephalopathy

When to Seek Medical Attention Any person who displays altered mental function, unexplained confusion, seizure, weakness, or unresponsiveness should receive medical attention [healthcare-online.org]

Hypotension, unresponsive to volume expansion, points to intoxication with barbiturates or opiates, myxedema, or Addisonian crisis. [aneskey.com]

He had been found unresponsive in his apartment. He was last seen 24-hours earlier by his friends at a social gathering, where his behavior was apparently normal. [dartmouth.edu]

Syncope

[…] head Administer aromatic ammonia inhalant Reevaluate vital signs If patient’s condition deteriorates Activate EMS Monitor vital signs If at any time the patient becomes unresponsive [dentalcare.com]

You become unresponsive, lose muscle tone and may fall. Its occurrence is fairly common and increases with age. [luriechildrens.org]

[…] called angioneurotic edema) Allergy testing A low blood sugar level (hypoglycemia) Fainting after a period of other symptoms, including confusion, shakiness, and sweating Unresponsiveness [msdmanuals.com]

Liver Cirrhosis

Early signs of toxin accumulation in the brain ( Hepatic Encephalopathy ) may include neglect of personal appearance, unresponsiveness, forgetfulness, concentration problems [liver.ca]

Tolerance is defined as a state of donor-specific unresponsiveness without a need for ongoing immunosuppression. Another alternative is bio-integration. [eureka.criver.com]

With time, hepatic encephalopathy can progress to unresponsiveness or coma. Jaundice. [mayoclinic.org]

Apallic Syndrome

We here offer physicians the possibility to refer to this condition as unresponsive wakefulness syndrome or UWS. [ncbi.nlm.nih.gov]

Abstract Background Some patients awaken from coma (that is, open the eyes) but remain unresponsive (that is, only showing reflex movements without response to command). [springermedizin.de]

Formerly called Apallic syndrome or Persistent Vegetative State (PVS). [1] Unresponsive Wakefulness Syndrome (UWS) is a very serious brain damage, when cortical parts of the [wikilectures.eu]

Vegetative State

Abstract Predicting recovery of consciousness in patients who survive their coma but evolve to a vegetative state (recently coined unresponsive wakefulness syndrome) remains [ncbi.nlm.nih.gov]

Abstract One of the worst outcomes of acquired brain injury is the vegetative state, recently renamed 'unresponsive wakefulness syndrome' (VS/UWS). [ncbi.nlm.nih.gov]

The Unresponsive Wakefulness Syndrome (UWS) could replace the VS/AS nomenclature in science and public with social competence. [ncbi.nlm.nih.gov]

Schizophrenia

Using this rating, we assessed all trials of atypicals in schizophrenia unresponsive to at least one drug. [ncbi.nlm.nih.gov]

We report a case of premenstrual mood changes in a patient with schizophrenia who was unresponsive to conventional treatment but successfully managed with dienogest. [ncbi.nlm.nih.gov]

While many antipsychotics have been demonstrated as effective in the treatment of schizophrenia, a substantial number of schizophrenia patients are partially or fully unresponsive [ncbi.nlm.nih.gov]

Encephalitis

Clinicians should be wary of this condition, especially when assessing patients with recent onset of psychiatric symptoms unresponsive to antipsychotic treatment. [ncbi.nlm.nih.gov]

[…] lethargy, inattention or temper-tantrums) and cognitive decline Stage II Myoclonic jerks, seizures and dementia Stage III Rigidity, extra-pyramidal symptoms, progressive unresponsiveness [doi.org]

In the case of rapidly increasing intracranial pressure with clinical deterioration unresponsive to medical treatment, very serious consideration should be given to surgical [doi.org]

Shock

• If they become unresponsive at any point, open their airway, check their breathing, and prepare to treat someone who has become unresponsive. [sja.org.uk]

Dizziness or fainting Weakness Depending on the type of shock the following symptoms may also be observed: Eyes appear to stare Anxiety or agitation Seizures Confusion or unresponsiveness [medicinenet.com]

Bipolar Disorder

He was unresponsive to the usual pharmacotherapies for bipolar disorders such as mood stabilizers and second-generation antipsychotics. [ncbi.nlm.nih.gov]

Management Lithium prevents or attenuates manic and depressive episodes, maintained at 0.8–1.0 mmol/L; if the manic episode is unresponsive, electroconvulsive therapy may [medical-dictionary.thefreedictionary.com]

[…] after other treatments (such as medication or psychotherapy) are tried, or in cases where rapid response is needed, as in the case of suicide risk and catatonia (a state of unresponsiveness [nimh.nih.gov]

Stroke

He was unresponsive, which was attributed to alcohol intoxication. [ncbi.nlm.nih.gov]

For example, if people are in a coma or unresponsive (as may result from brain herniation), mechanical ventilation (with a breathing tube inserted through the mouth or nose [msdmanuals.com]

All participants presented within 24 hours of the cerebral event and with a score less than 80 on the Orgogozo Functional Scale (0 = completely unresponsive, 100 = no deficit [doi.org]

Viral Meningitis

People with this condition may have the following symptoms: Headache Neck stiffness Sensitivity to light Increased sleepiness Unresponsiveness Fever Nausea, vomiting Lack [dshs.state.tx.us]

being sick a headache a blotchy rash that doesn't fade when a glass is rolled over it (this won't always develop) a stiff neck a dislike of bright lights drowsiness or unresponsiveness [nhsdirect.wales.nhs.uk]

She's drowsy, floppy or unresponsive. Her crying is unusually high-pitched. She is vomiting, and refusing to feed She has cold hands and feet. [babycentre.co.uk]

Dementia

[…] patterns sudden changes in mood or personality hallucinations or delusions difficulty concentrating or focusing on a single subject disorganized thinking, speech, or behavior unresponsiveness [medicalnewstoday.com]

Use of benzodiazepines should be reserved for alcohol withdrawal symptoms/delirium tremens or severe generalized anxiety disorder unresponsive to other therapies. 5 Don’t [choosingwisely.org]

[…] focal, medically refractory epilepsy and show parieto-occipitally brain calcifications on CT or MRI, response to AED alone appears to be poor with the majority (73%) being unresponsive [doi.org]

Brain Abscess

The headache is usually very severe (unresponsive to over-the-counter pain medications) and ipsilateral to the site of the abscess. [symptoma.com]

Usually, the headache occurs on the side of the head where the abscess is located and it is often unresponsive to over-the-counter pain killers. [symptoma.com]

Narcolepsy

We also explain that the unresponsiveness decreases somewhat as the patient becomes used to the medication. [doi.org]

African Trypanosomiasis

Combination therapies have been used on a compassionate basis in patients unresponsive to other drugs. [doi.org]

Status Asthmaticus

OBJECTIVE: To evaluate the quality of available evidence to establish guidelines for the use of noninvasive ventilation for the management of status asthmaticus in children unresponsive [ncbi.nlm.nih.gov]

PATIENT SELECTION: Children with SA unresponsive to conventional therapy with a modified Wood's clinical asthma score (m-WCAS) ≥4 and marked increased work of breathing, were [ncbi.nlm.nih.gov]

Conclusion: The results suggest that noninvasive ventilation is applicable for the treatment of status asthmaticus in most pediatric patients unresponsive to standard treatment [scielo.br]

Narcolepsy Type 3

Nanophthalmos-1 NNO3 nanophthalmos 3 2q11-q14 Nanophthalmos 3 NNT nicotinamide nucleotide transhydrogenase 5p12 Glucocorticoid Deficiency 4, Glucocorticoid Deficiency, Due To Acth Unresponsiveness [genecards.weizmann.ac.il]

Cardiopulmonary Resuscitation

If an adult is unresponsive and not breathing, you’ll need to do CPR (which is short for cardiopulmonary resuscitation). [sja.org.uk]

If you’re trained in CPR and come across someone who’s unresponsive or having difficulty breathing, follow the steps for hands-only CPR for 30 chest compressions. [healthline.com]

If the person does not respond to your voice or touch, they are unresponsive. If the victim is unresponsive and you are alone, leave the victim and immediately call 911. [emedicinehealth.com]

Minimally Conscious State

The goal of our study was to investigate different aspects of sleep, namely the sleep-wake cycle and sleep stages, in the vegetative state/unresponsive wakefulness syndrome [ncbi.nlm.nih.gov]

Mean EEG entropy values were higher in minimally conscious (73±19; mean and standard deviation) than in vegetative/unresponsive wakefulness syndrome patients (45±28). [eprints.bice.rm.cnr.it]

Disorders of consciousness (DOC) diagnosis relies on the presence or absence of purposeful motor responsiveness, which characterizes the minimally conscious state (MCS) and the unresponsive [ncbi.nlm.nih.gov]

Postictal State

For generalized tonic-clonic seizures, where the entire brain is eventually involved, the postictal state can consist of complete unresponsiveness with gradual recovery associated [sharecare.com]

When you arrive, the patient is on the floor of the dorm, unresponsive and twitching. What do you do? [jailmedicine.com]

Brief loss of consciousness Interrupted motion or activity, blank stare, unresponsiveness Can occur several hundred times a day and usually ceases after 5–20 seconds Very [amboss.com]

Methylmalonic Acidemia

Clinical description Patients with vitamin B12-unresponsive methylmalonic acidemia without homocystinuria typically present very early in life (<1 to 4 weeks) with features [orpha.net]

The mechanism of nephrotoxicity in vitamin B12-unresponsive MMA is not yet known. [ncbi.nlm.nih.gov]

The biochemical and therapeutic responses to dietary therapy were studied in a 25-month-old girl and a 1-month-old girl with methylmalonic acidemia (MMA-emia), which was unresponsive [ncbi.nlm.nih.gov]

Beta Blocker Poisoning

Reserve cardiac pacing for patients unresponsive to pharmacologic therapy or for those with torsade de pointes unresponsive to magnesium. [emedicine.medscape.com]

Use pacing, either TCP or TVP, for bradycardia that is unresponsive to the preceding therapies. [calsprogram.org]

[…] with fluids initially Add adrenaline infusion if not responding to fluids Atropine aliquots can also be considered for bradycardia Pacing may be necessary if bradycardia is unresponsive [emergpa.net]

Brain Death

The diagnosis of brain death requires the presence of unresponsiveness and a lack of receptivity, the absence of movement, breathing and brain stem reflexes, as well as a [ncbi.nlm.nih.gov]

[…] consecutive formal neurological examinations to document total loss of consciousness and absence of brain stem reflexes and then apnea testing to evaluate carbon dioxide unresponsiveness [ncbi.nlm.nih.gov]

A 40-year-old woman was found unresponsive by her family. Baclofen was found to be the responsible overdose. [ncbi.nlm.nih.gov]

Cystathioninuria

Neither an increase in cystathionase activity nor immunochemical identity was found using extract of cells from a B6-unresponsive patient. [ncbi.nlm.nih.gov]

One form of cystathioninuria, vitamin B 6 -unresponsive, appears to result from absence of synthesis of the enzyme protein. [doi.org]

There is vitamin B6 – unresponsive and vitamin B6 – responsive cystathioninuria. [en.wikipedia.org]

Panayiotopoulos Syndrome

He fell on the floor and remained unresponsive and flaccid for 20 minutes and then he rapidly recovered. [en.wikipedia.org]

In at least a fifth of the seizures the child becomes unresponsive, pale, and flaccid (ictal syncope)4 either before convulsing or in isolation. [ncbi.nlm.nih.gov]

At age 20 months, he collapsed on the floor pale, unresponsive, and flaccid for approximately 10 minutes. [en.wikipedia.org]

Neonatal Diabetes Mellitus

/ Glibenclamide Unresponsiveness in a Brazilian Child with Permanent Neonatal Diabetes Mellitus and DEND Syndrome Due to a C166Y Mutation in KCNJ11 (Kir6.2) Gene. [discovery.dundee.ac.uk]

CLINICAL CASE REPORT Glibenclamide unresponsiveness in a Brazilian child with permanent neonatal diabetes mellitus and DEND syndrome due to a C166Y mutation in KCNJ11 (Kir6.2 [scielo.br]

DEND syndrome due to V59A Mutation in the KCNJ11 gene: unresponsive to sulfonylureas. [diabetesresearchclinicalpractice.com]