Precocious Puberty: Causes & Reasons

Possible Causes for Precocious Puberty

The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. [profiles.umassmed.edu]

The hormone may produce precocious puberty in children and cause endometrial hyperplasia in women. [web.archive.org]

puberty. 2,3 In pregnancy, hormonal symptoms are temporized, thus the most common presentation is acute rupture. [mdedge.com]

Hypothalamic Hamartoma

We report an interesting case of hypothalamic hamartoma causing precocious puberty in a young male. [ncbi.nlm.nih.gov]

Zuniga OF, Tanner SM, Wild WO, Mosier HD Jr: Hamartoma of CNS associated with precocious puberty. Am J Dis Child 1983;137:127–133. [karger.com]

To report a rare case of central precocious puberty attributable to hypothalamic hamartoma that was diagnosed in utero. [ncbi.nlm.nih.gov]

Leydig Cell Tumor

We report two boys who developed true precocious puberty after surgical treatment of a Leydig cell tumor of the testis that presented peripheral precocious puberty. [frontiersin.org]

In children, excess testosterone results in the development of precocious puberty - the early growth of pubic hair, the penis and the musculoskeletal system. [symptoma.com]

Therefore, non-organic central precocious puberty was diagnosed. [frontiersin.org]

Precocious Puberty

Cerebral precocious puberty differs in cause but mimics true precocious puberty. [healthcentral.com]

How Do We Define Precocious Puberty? [ndnr.com]

In boys, precocious puberty is more likely to be linked to hypothalamic lesions (≈40%). [touchendocrinology.com]

Septo-Optic Dysplasia

The patient also showed central precocious puberty in addition to GH and ATCH deficiency. [omicsonline.org]

The clinical manifestations include poor visual function in one or both eyes, developmental delay, seizures, sleep disturbances, and precocious puberty. [ncbi.nlm.nih.gov]

puberty development. [ncbi.nlm.nih.gov]

Sertoli Leydig Cell Tumor

[…] hormone stimulation test confirmed central precocious puberty. [ncbi.nlm.nih.gov]

Gonadotropin-independent precocious puberty. Endocrinol Metab Clin North Am 1991 ;20: 191 - 210 24. [nejm.org]

Página 84 - Somatomedin-C in normal puberty and in true precocious puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist. ‎ [books.google.es]

Adrenocortical Hyperplasia

( Q78.1 ) central precocious puberty ( E22.8 ) congenital adrenal hyperplasia ( E25.0 ) female heterosexual precocious pseudopuberty ( E25.- ) male isosexual precocious pseudopuberty [icd10data.com]

In addition, 11-β hydroxylase deficiency cases showed precocious puberty with testicular adrenal rest tumor and adrenal myelolipoma, whereas the patient with 17-α hydroxylase [turkjem.org]

puberty in affected males ◦ virilization or sexual infantilism in affected females 7. [slideshare.net]

McCune-Albright Syndrome

[…] condition, gonadotropin-independent precocious puberty without the bone disease polyostotic fibrous dysplasia. [clinicaltrials.gov]

She was diagnosed with gonadotropin independent precocious puberty with eventual progression to gonadotropin dependent precocious puberty which was successfully treated with [ncbi.nlm.nih.gov]

Gonadotropin-independent precocious puberty is the most common endocrine involvement described. [ijp.mums.ac.ir]

Polyostotic Fibrous Dysplasia

Clinical findings Precocious puberty, polyostotic (cystic fibrous dysplasia) spontaneous fractures at young age, café-au-lait spots on skin, ovarian cysts. [medical-dictionary.thefreedictionary.com]

Puberty — Albright's Syndrome with Precocious Puberty — Albright-Mccune-Sternberg Syndrome — Albright-Sternberg Syndrome — Albright's Syndrome — Syndrome, Albright's — Albright's [mesh.kib.ki.se]

Albright's syndrome is characterized by the combination of polyostotic fibrous dysplasia, precocious puberty and café-au-lait spots. [ncbi.nlm.nih.gov]

Malignant Neoplasm of the Ovary

puberty, early sexual maturity; amenorrhea, absence/stopping of the menstrual period; or postmenopausal bleeding. [healthcommunities.com]

Menstrual irregularities such as postmenopausal bleeding and metrorrhagia Increased risk of endometrial cancer Precocious puberty Sertoli-Leydig cell tumor: can produce either [amboss.com]

puberty. [glowm.com]

Adrenocortical Carcinoma

Features of hetro-sexual precocious puberty in a girl should alert the possibility of such a rare disease. [ncbi.nlm.nih.gov]

The second case narrates the intra-operative imprint cytology findings in a 2-year-old boy who came with precocious puberty. [ncbi.nlm.nih.gov]

puberty, using an atrophic left adrenal gland removed at the time of tumorectomy as a control. [ncbi.nlm.nih.gov]

Williams-Beuren Syndrome

Poor growth potential is further affected by central precocious puberty (CPP) which is frequent in these patients. [ncbi.nlm.nih.gov]

puberty in girls with Williams syndrome. [malattierare.regione.veneto.it]

puberty (50%). [clinicaladvisor.com]

Schimmelpenning-Feuerstein-Mims Syndrome

As part of these manifestations, rarely, central precocious puberty can arise. [hindawi.com]

Moreover, the patient developed a precocious puberty at the age of 9 years. [pubmed.ncbi.nlm.nih.gov]

Ivker R, Resnick S, Skidmore RA: Hypophosphatemic vitamin-D-resistant rickets, precocious puberty, and the epidermal nevus syndrome. Arch Dermatol 1997;133:1557–1561. [karger.com]

Congenital Adrenal Hyperplasia

puberty at age 2–4 Females present with ambiguous genitalia Normal external genitalia at birth in both genotypes Precocious puberty Acne Infertility Females may also have [amboss.com]

In childhood the main challenge is controlling excessive growth and precocious puberty and if this is not well controlled then patients will have an early puberty and ultimately [diurnal.co.uk]

The aim is to prevent neonatal death, determine the sex and prevent precocious puberty. [tidsskriftet.no]

Hyperplasia of the Leydig Cells

Gonadotropin-independent precocious puberty. Endocrinol Metab Clin North Am 1991 ;20: 191 - 210 24. [nejm.org]

Clinical findings Precocious puberty. Management Orchidectomy. [medical-dictionary.thefreedictionary.com]

Tumor cells may produce androgen, estrogens or both and presents with gynecomastia or precocious puberty; symptoms usually regress with excision. [auanet.org]

Hydrocephalus

Consequences of chronic hydrocephalus may include precocious puberty in girls, learning disorders (eg, difficulties with attention, information processing, and memory), loss [merckmanuals.com]

Enlargement of the third ventricle can lead to precocious puberty and short stature. [lecturio.com]

Brain Neoplasm

puberty (especially in boys), hypothermia Astrocytoma Occipital lobe Generalized seizures with visual aura, visual hallucinations, hemianopia or quadrantanopia (contralateral [merckmanuals.com]

[…] tumor is in dominant hemisphere Anosmia if tumor is at base of lobe Astrocytoma Glioblastoma Oligodendroglioma Hypothalamus Eating and drinking disorders (eg, polydipsia), precocious [merckmanuals.com]

Adrenal Cortex Tumor

puberty in the male. [accessmedicine.mhmedical.com]

puberty in children Who Performs Adrenal Hormone Tests A doctor, a nurse, or a technician Special Concerns about Adrenal Hormone Tests A nuclear scan performed within the [healthcommunities.com]

Most tumors in children are functional, and virilization is by far the most common presenting symptom, followed by Cushing's syndrome and precocious puberty. [1] Among adults [en.wikipedia.org]

Constitutional Symptom

Endocrine symptoms such as growth arrest, diabetes insipidus, and precocious or delayed puberty may be signs of endocranial or germ cell tumors. [aafp.org]

Gonadotropin-dependent precocious puberty: neoplastic causes and endocrine considerations. Int J Pediatr Endocrinol. 2011;2011(1):184502. 31. [aafp.org]

puberty, and pubertal delay. [aafp.org]

Androgens

puberty and short stature • Acne • Hepatic carcinoma````` • Gynaecomastia 17. [slideshare.net]

In both males and females, too much testosterone can lead to precocious puberty and result in infertility. [yourhormones.info]

puberty in Boys • Inappropriate sexual behaviour in men • Virilization in women • Limited use 23. [slideshare.net]

Pineal Gland Cyst

Precocious puberty in children with tumours of the suprasellar and pineal areas: organic central precocious puberty. Acta Paediatr 2001; 90: 751–756. [link.springer.com]

They also denied any family history of precocious puberty or exposure to medications by the child. [indianpediatrics.net]

puberty, and recently described occurrence of secondary parkinsonism. [ncbi.nlm.nih.gov]

Estrogenic Agents

Increased levels of estradiol (E2) or estrone (E1) are seen in: Girls and Women: Early (precocious) puberty Tumors of the ovary or adrenal glands Boys and Men: Enlarged breasts [labtestsonline.org]

Estradiol or other hormone levels may be tested in the evaluation of precocious puberty in girls (the onset of signs of puberty before age seven), delayed puberty and in assisted [healthywomen.org]

Endocrine Dysfunction

At 12 months after injury, 14% had precocious puberty, 9% had hypothyroidism, and 5% had growth hormone deficiency. [ncbi.nlm.nih.gov]

Puberty is considered precocious in girls younger than 8 years. For boys, onset of puberty before age 9 years is considered precocious. [hopeforhh.org]

puberty), hydrocephalus emerged as an independent risk factor for precocious puberty only. [ascopubs.org]

Sertoli Leydig Cell Tumor of the Ovary

Register Aldosteronism and Precocious Puberty Due to an Ovarian Androblastoma (Sertoli Cell Tumor)¹ - 24 Hours access EUR €27.00 GBP £20.00 USD $35.00 Rental This article [academic.oup.com]

Register Aldosteronism and Precocious Puberty Due to an Ovarian Androblastoma (Sertoli Cell Tumor) ¹ - 24 Hours access EUR €36.00 GBP £28.00 USD $45.00 Rental This article [academic.oup.com]

A case of androblastoma with not only signs of virilization but also manifestations of precocious puberty occurring in a five-year-old girl is presented. [ncbi.nlm.nih.gov]

Lipid Cell Tumor of the Ovary

The girl developed precocious puberty again 2 years later without any sign of relapse. [link.springer.com]

Página 84 - Somatomedin-C in normal puberty and in true precocious puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist. ‎ [books.google.es]

These tumors should be considered in the differential diagnosis of isosexual precocious puberty in children and virilization in adults. [ncbi.nlm.nih.gov]

Suprasellar Tumor

Disorders of pubertal development include delayed puberty and precocious puberty. [fdocuments.net]

Clinical symptoms include diabetes insipidus, precocious puberty, or growth failure related to hypothalamic involvement and visual loss provoked by chiasmatic compression. [link.springer.com]

Different mechanisms result in the development of precocious puberty in the two sexes. [tandfonline.com]

Hilar Cell Tumor of the Ovary

Página 84 - Somatomedin-C in normal puberty and in true precocious puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist. ‎ [books.google.es]

The hormone may produce precocious puberty in children and cause endometrial hyperplasia in women. [bioscience.org]

These tumors should be considered a cause of isosexual precocious puberty in children and virilization in adults. [ovarianresearch.biomedcentral.com]

Adrenogenital Syndrome

All 3 patients had a history of precocious puberty. [ncbi.nlm.nih.gov]

They include: endocrine disorders idiopathic isosexual precocious puberty hypothalamic or parathalamic lesion with sexual precocity: e.g. craniopharyngioma astrocytoma hypothalamic [radiopaedia.org]

It may cause masculinization in girls, precocious puberty in boys, and adrenocortical failure ( see Addison’s disease) in both sexes. [oxfordreference.com]

Leydig Cell Tumor of the Testis

A case of right testicular Leydig cell tumor in a 10 1/2-year-old child with precocious puberty is reported. [ncbi.nlm.nih.gov]

We report two boys who developed true precocious puberty after surgical treatment of a Leydig cell tumor of the testis that presented peripheral precocious puberty. [frontiersin.org]

When it occurs in children, it is frequently accompanied by precocious puberty. [jpatholtm.org]

Multiple Ovarian Cysts

A 7-year, 8-month-old girl presented with precocious puberty and vaginal bleeding. [ncbi.nlm.nih.gov]

Some reports have been published of primary hypothyroidism presenting as ovarian cysts and precocious puberty in prepubertal girls. [ncbi.nlm.nih.gov]

Bidlingmaier F, Butenandt O, Knorr D (1977) Plasma gonadotropins and estrogens in girls with idiopathic precocious puberty. Pediatr Res 11:91–94 Google Scholar 2. [link.springer.com]