Lactate Decreased: Causes & Reasons

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Possible Causes for Lactate Decreased

Acidosis

The patient's lactate level decreased about 2 weeks after discharge. [nature.com]

The ability of the liver to consume lactate is concentration-dependent and progressively decreases as the level of blood lactate increases. [emedicine.medscape.com]

In the setting of decreased tissue oxygenation, pyruvate is not readily metabolized and its intracellular levels rise, causing lactate levels to rise proportionally. [emedicine.medscape.com]

Cardiogenic Shock

RESULTS: At 24 h, lactate decreased from 3.2 (2.1-6.8) to 1.8 (1.2-2.2) mmol/L (p < 0.001). [ncbi.nlm.nih.gov]

Active MCS significantly increased MAP (MD 11.85 mmHg, 95% CI 3.39 to 20.31, P = 0.02, I2 = 32.7%) and decreased arterial lactate (MD - 1.36 mmol/L, 95% CI - 2.52 to - 0.19 [ncbi.nlm.nih.gov]

Pulmonary Congestion Impaired organ perfusion cold clammy skin decreased urine output altered mental state raised serum lactate Our patient fulfilled almost all of these criteria [resus.com.au]

Metabolic Acidosis

Decreased unmeasured cations: hypocalcemia, hypokalemia, hypomagnesemia. [globalrph.com]

Several studies report the additional prognostic usefulness of plasma lactate decrease (clearance). [annalsofintensivecare.springeropen.com]

Lactate accumulation results from a combination of excess formation and decreased metabolism of lactate. [merckmanuals.com]

Psychogenic Hyperventilation

In contrast, they found that three of three studies of respiratory acidosis and seven of nine studies of metabolic acidosis reported a decrease in net lactate production. [journals.sagepub.com]

[…] above the reference range with no adverse events or requirement for medication.6 Lactic acid production decreases when intracellular pH is low (acidosis) and increases when [journals.sagepub.com]

[…] changes in acid–base status, Hood and Tannen found that 12 of 12 studies of respiratory alkalosis and 12 of 15 studies of metabolic alkalosis observed an increase in net lactate [journals.sagepub.com]

Mesenteric Infarction

A positive laparotomy (n = 13) was associated with no change in D-lactate (P = 0.95), decreased i-FABP (P = 0.007), and increased SMA (P = 0.01). [ncbi.nlm.nih.gov]

Clinical presentation of NOMI is manifold and poses a diagnostic challenge, as clinical signs such as oliguria, rising serum lactate levels, decreased blood oxygenation, hypertension [journals.plos.org]

Patients may present with lactic acidosis due to dehydration and decreased oral intake. [wjes.biomedcentral.com]

Hypoxia

It was indicated that hypoxia led to an increase in lactate secretion and a decrease in MPC1 and MPC2 levels, which were upregulated following re‑oxygenation. [ncbi.nlm.nih.gov]

Notably, the downregulation of HKII resulted in a significant decrease of TSCC cell glucose consumption lactate production and autophagic activity during hypoxia. [ncbi.nlm.nih.gov]

Lung examination revealed decreased breath sounds bilaterally, and the remainder of the examination was unrevealing. [ncbi.nlm.nih.gov]

MELAS Syndrome

Blood lactate and pyruvate concentration decreased by 50% within three days and 24 h urine lactate content within 2 weeks and we observed a clinical improvement together with [ncbi.nlm.nih.gov]

Serum lactate elevation, mosaic pattern of COX deficit and decreased activity of complex I and IV in the muscle biopsy were found in all cases. [ncbi.nlm.nih.gov]

Proton MRS of the lesion showed a lactate peak, N-acetylaspartate level decrease, and slight reduction in choline level. [neurologyindia.com]

Preeclampsia

In this situation, the patient should be hydrated with an infusion of 1,000 mL lactated ringer or saline before sympathetic block to avoid severe hypotension with decreased [scielo.br]

LDH=Lactate dehydrogenase, Uric acid=Uric acid, AST=Aspartate aminotransferase, ALT=Alanine aminotransferase, Plt=Platelets, Cr=Creatinine. [en.wikipedia.org]

[…] maternal spiral arteries, causing high resistance and low blood flow and low nutrient supply to the fetus.[17] There is tentative evidence that vitamin supplementation can decrease [en.wikipedia.org]

Status Epilepticus

In the initial phase of GCSE, blood pressure, glucose, and lactate increase, and pH decreases. [ccforum.biomedcentral.com]

During this second phase, blood pressure and glucose normalize (sometimes decreasing even further), lactate normalizes, and respiratory compromise and hyperthermia ensue [ [ccforum.biomedcentral.com]

Status Asthmaticus

lactate clearance by the liver because of hypoperfusion. [pubmedcentral.nih.gov]

[…] metabolism of the ventilatory muscles and overproduction of lactic acid; the eventually coexisting profound tissue hypoxia; the presence of intracellular alkalosis; and the decreased [pubmedcentral.nih.gov]

Glycogen Storage Disease Type 1

Blood lactate concentrations decrease after an oral glucose load. The liver typically is markedly enlarged causing a protuberant abdomen. [clinicaladvisor.com]

Intracerebral ratios of glucose and lactate to creatine were higher in GSD1 patients (P < 0.05 vs. control). [ncbi.nlm.nih.gov]

In individuals suffering from GSD type 1, serum glucose and blood pH levels are often decreased but the cholesterol levels, triglyceride, serum lactate and uric acid are elevated [symptoma.com]

Septic Shock

[…] in the blood Decreased capillary filling or mottling Medical Disclaimer The information on or available through this site is intended for educational purposes only. [sepsis.org]

Epinephrine decreases splanchnic blood flow, gastric mucosal pH, and splanchnic oxygen consumption and increases blood lactate concentrations in patients with sepsis. 2, 3 [content.nejm.org]

lactate). [emergencymedicinecases.com]

Embolic Mesenteric Infarction

Patients may present with lactic acidosis due to dehydration and decreased oral intake. [wjes.biomedcentral.com]

The second most commonly encountered abnormal finding is metabolic acidosis with elevated lactate level, which occurred in 88% [ 24 ]. [wjes.biomedcentral.com]

Thus, differentiation of early ischemia versus irreversible bowel injury based upon the lactate level alone is not reliable unless accompanied by other clinical evidence. [wjes.biomedcentral.com]

Intestinal Infarction

Patients may present with lactic acidosis due to dehydration and decreased oral intake. [wjes.biomedcentral.com]

The second most commonly encountered abnormal finding is metabolic acidosis with elevated lactate level, which occurred in 88% [ 24 ]. [wjes.biomedcentral.com]

Thus, differentiation of early ischemia versus irreversible bowel injury based upon the lactate level alone is not reliable unless accompanied by other clinical evidence. [wjes.biomedcentral.com]

Liver Failure

Additionally, there is intra- and extra-pulmonary shunting, elevated mixed venous oxygen saturation (SvO2), altered lactate metabolism. [intechopen.com]

The hyperdynamic circulation is a result of decreased systemic vascular resistance (SVR) and compensatory increased cardiac output to maintain tissue perfusion. [intechopen.com]

Shock

Serial measurements of ABGs, hematocrit, electrolytes, serum creatinine, and blood lactate are obtained. [merckmanuals.com]

Sublingual carbon dioxide measurement, if available, is a noninvasive monitor of visceral perfusion (levels increase with decreasing tissue perfusion). [merckmanuals.com]

Folate-Deficiency Anemia

[…] hepatic levels of dihydrofolate reductase) Congenital deficiency of enzymes of folate metabolism Increased requirement: infancy, pregnancy, lactation, malignancy, concurrent [pathologyoutlines.com]

[…] strictures, jejunal diverticula Impaired metabolism, leading to inability to utilize absorbed folate: methotrexate and trimethoprim (folate antagonists) Hypothyroidism (decreases [pathologyoutlines.com]

Metachromatic Leukodystrophy

Spectroscopy confirmed a decrease in the NAA/Cr ratio, an increase in the Cho/Cr ratio and in myo-inositol, and a lactate resonance. [ncbi.nlm.nih.gov]

Anxiety Disorder

Generalized anxiety disorder is a chronic condition characterized by beliefs that worry prepares and protects, but that excessive worry is out of control. In this article, I review the cognitive-behavioral model of generalized anxiety, focusing specifically on problems related to excessive worrying. Noncompliance in[…] [ncbi.nlm.nih.gov]

Congestive Heart Failure

Congestive heart failure occurs when the heart can no longer meet the metabolic demands of the body at normal physiologic venous pressures. Typically, the heart can respond to increased demands by means of 1 of the following: Increasing the heart rate, which is controlled by neural and humoral input Increasing[…] [emedicine.com]

Acute Myocardial Infarction

We herein report the case of a 25-year-old Japanese woman with left-main-trunk acute myocardial infarction (LMT-AMI). She had cardiogenic shock, so emergency percutaneous intervention was performed. Intravascular ultrasound of LMT-AMI showed that the three-layered structure of the intima, tunica media, and[…] [ncbi.nlm.nih.gov]

Chronic Right-Sided Congestive Heart Failure

Home | CCC | Right Ventricular Failure by, last update March 24, 2019 Reviewed and revised 26 June 2014 OVERVIEW mortality as high as LV failure RV is better suited to volume overload than left due to compliance and thin wall but when PVR increases for whatever reason -> RV dilates when the dilation maximised ->[…] [lifeinthefastlane.com]

Epilepsy with Generalized Tonic-Clonic Seizures

Definition (MSH) A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation,[…] [fpnotebook.com]

Mesenteric Vein Thrombosis

Mesenteric venous thrombosis (MVT) is an uncommon clinical condition with potential high morbidity. We report here a patient who presented with acute-onset MVT and bowel infarction, which was successfully ameliorated with intramesenteric vein thrombolytic therapy. [ncbi.nlm.nih.gov]

Cardiac Arrest

Cardiac arrest Other names Cardiopulmonary arrest, circulatory arrest, sudden cardiac arrest (SCA), sudden cardiac death (SCD)[1] CPR being administered during a simulation of cardiac arrest. Specialty Cardiology, emergency medicine Symptoms Loss of consciousness, abnormal or no breathing[1][2] Usual onset Older[…] [en.wikipedia.org]

Multiple Sclerosis

Multiple sclerosis (MS) is the most common chronic disabling disease of the central nervous system (CNS) in young adults. It is characterized by the presence of multiple demyelinating inflammatory lesions disseminated in the CNS. Pseudotumoral lesions (PL) are rarely observed in patients with MS. These atypical lesions[…] [ncbi.nlm.nih.gov]

Toxic Shock Syndrome

Toxic shock syndrome (TSS) is a condition caused by bacterial toxins. Symptoms may include fever, rash, skin peeling, and low blood pressure. There may also be symptoms related to the specific underlying infection such as mastitis, osteomyelitis, necrotising fasciitis, or pneumonia.TSS is caused by bacteria of either[…] [en.wikipedia.org]

Familial Periodic Paralysis

Periodic paralysis is a group of rare genetic diseases that lead to weakness or paralysis from common triggers such as cold, heat, high carbohydrate meals, not eating, stress or excitement and physical activity of any kind. The underlying mechanism of these diseases are malfunctions in the ion channels in skeletal[…] [en.wikipedia.org]

Aerobic Exercise

CONCLUSIONS: Greater decrease in lower limb PWV occurred after IE despite greater heart rate. [ncbi.nlm.nih.gov]

Lactate concentration was controlled every fifth training day. [bjsm.bmj.com]

This may be due to the higher blood levels of lactate during IE, while NO, ANP, noradrenaline, and adrenaline levels remained not statistically different from CE. [ncbi.nlm.nih.gov]

Ischemic Gangrene

Images in Clinical Medicine Zhu Shen, M.D., Ph.D., and Qingyi Ye, M.D. An 88-year-old man who reported he did not smoke and who had a long-standing history of diabetes mellitus, hypertension, and hypercholesterolemia was admitted to the hospital with a 4-month history of painful and progressive ischemic gangrene of the[…] [nejm.org]