HLA-DQ2: Causes & Reasons - Symptoma Ireland

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Possible Causes for HLA-DQ2

Celiac Disease

HLA-DQ2 was less frequent in UC patients ( P = 0.0287), and HLA-DQ8 in CD ( P = 0.0217). [ncbi.nlm.nih.gov]

The disease is associated with human HLA-DQ genes encoding HLA-DQ2 and DQ8 proteins. [ncbi.nlm.nih.gov]

HLA-DQ2 and Presentation of Gliadin Epitopes. [doi.org]

Childhood Celiac Disease

HLA-DQ2 and HLA-DQ8 Genes 95% of people with celiac disease have either or both of the HLA-DQ2 or HLA-DQ8 genes. [beyondceliac.org]

The most important genes associated with susceptibility to coeliac disease are HLA DQ2 and HLA DQ8. [coeliac.org.au]

Methods We performed a multicenter, randomized, double-blind, placebo-controlled dietary-intervention study involving 944 children who were positive for HLA-DQ2 or HLA-DQ8 [drschaer-institute.com]

Celiac Disease with Diffuse Intestinal Ulceration

Past genetic testing revealed that this patient carries the HLA-DQ2 allele. The physician suspects that the patient's presentation is dietary in cause. [medbullets.com]

DQ2 or DQ8 expression, dermatitis herpetiformis, hyposplenism Monomorphic variant NOT associated with celiac disease, may represent a distinct entity EATL in situ: refractory [pathologyoutlines.com]

Celiac Disease and HLA-DQ2/DQ8 eMedicine [On-line information]. [labtestsonline.it]

Chronic Diarrhea with Villous Atrophy

However, as two copies of HLA-DQ2 have been reported to enhance the predisposition to celiac disease [ 14 ], we investigated the number of HLA-DQ2 copies according to the [em-consulte.com]

[…] olmesartan-associated sprue-like enteropathy is uncertain, the long latency before onset of symptoms, findings of lymphocytic or collagenous colitis, and high association with HLA-DQ2 [medpagetoday.com]

As for isolated CD, CEC is associated with the HLA-DQ2 and HLA-DQ8 genes. [orpha.net]

Dermatitis Herpetiformis

No patients had HLA-DQ2 or -DQ8, which is frequently found in Caucasian DH patients. [ncbi.nlm.nih.gov]

It is most common in patients of northern European/northern Indian ancestry, and is associated with the human leukocyte antigen (HLA) haplotype HLA-DQ2 or HLA-DQ8 along with [en.wikipedia.org]

Physiopathology is complex, occurring in HLA DQ2 or DQ8 predisposed patients, and implies gluten, immunological reaction in the intestinal wall then in the skin. [ncbi.nlm.nih.gov]

Autoimmune Polyendocrine Syndrome Type 2

Rather, individuals are at a higher risk when they carry a particular human leukocyte antigen (HLA-DQ2, HLA-DQ8 and HLA-DR4). [en.wikipedia.org]

Symptoms Asplenia[1] Risk factors Human leukocyte antigen (HLA-DQ2, HLA-DQ8 and HLA-DR4)[2] Diagnostic method Ultrasound, MRI[3] Treatment Thyroid-stimulating hormone[4] [en.wikipedia.org]

Autoimmune polyendocrine syndrome type 2 Other names Schmidt's syndrome[1] HLA-DQ2 one of the human leukocyte antigens genotypes responsible for this condition Specialty Endocrinology [en.wikipedia.org]

Enteropathy-Associated T-Cell Lymphoma

Homozygosity for HLA-DQ2 is associated with RCD II and EATL. [ncbi.nlm.nih.gov]

Cases with inappropriate HLA-DQ2/8 genotype testing. [doi.org]

Poor adherence to a gluten-free diet, HLA-DQ2 homozygosity, and late diagnosis of CD are recognized as risk factors for malignant evolution of CD. [ncbi.nlm.nih.gov]

Echinococcus Multilocularis Infection

PBMC from seven HLA-DR3+, DQ2+, B8+ healthy subjects and nine HLA-DR3-, DQ2-, B8- subjects were also studied as controls. [ncbi.nlm.nih.gov]

A spontaneous secretion of TNF by HLA DR3+, DQ2+ B8+ AE patients was also found. [ncbi.nlm.nih.gov]

DQ2+, B8+ AE patients and from 10 HLA-DR3-, DQ2-, B8- patients after non-specific mitogenic and specific Echinococcus multilocularis antigenic in vitro stimulation. [ncbi.nlm.nih.gov]

Tropical Sprue

- However, it is not known whether these antibodies are primary or secondary to the tissue damage. 15. 3) Genetic factor - Patients with coeliac disease express the HLA-DQ2 [slideshare.net]

More than 95% of celiac patients have the HLA-DQ2 or HLA-DQ8 haplotype ( 1 ), although these haplotypes are not particularly specific for celiac disease. [merckmanuals.com]

However, given the high sensitivity, testing that fails to show HLA-DQ2 or -DQ8 can effectively rule out celiac disease when biopsy and serologic markers are not concordant [merckmanuals.com]

Sjögren Syndrome

All were HLA-DQ2 and/or -DQ8-positive. [doi.org]

More than 95 % of those with CD express HLA-DQ2 while the remainder expresses HLA-DQ8. [doi.org]

Studies show an association with HLA-DQ2 and HLA-DQ8, the same HLA haplotypes necessary for the presence of CD [ 18, 20 ]. [doi.org]

Wheat Intolerance

It occurs in people who inherit one or both of the celiac genes (HLA-DQ2 & HLA-DQ8). [rebootwithjoe.com]

class II genes, HLA-DQ2 and HLA-DQ8, located on chromosome 6p21. [2] Nearly all CD patients are NLA-DQ2/HLA-DQ8 positive, with 95% HLA-DQ2 and the rest usually HLA-DQ8 [en.wikipedia.org]

DNA-based testing will identify the presence or absence of the genes encoding the gluten recognition immune cell receptors, HLA-DQ2 and DQ8. [precisionpath.us]

Selective IgA Immunodeficiency

Fifty-four out of 58 biopsy verified CD patients carried HLA-DQ2/DQ8 (one DNA sample was not available). [journals.plos.org]

Celiac Disease and HLA-DQ2/DQ8 eMedicine [On-line information]. [labtestsonline.it]

[…] disorder, triggered by gluten and related prolamines present in wheat, barley and rye, that occur in genetically susceptible individuals, who have the human leukocyte antigen HLA-DQ2 [medcraveonline.com]

Allergic Bronchopulmonary Aspergillosis

Previous HLA typing revealed that the patient was HLA-DR2+, DRB*1501, HLA-DQ2-, a pattern associated with increased risk of ABPA. [ncbi.nlm.nih.gov]

Additional studies indicated that the presence of HLA-DQ2 (especially HLA-DQB1*0201) provided protection from the development of ABPA. [clinicaladvisor.com]

Genetic Factors Involved in Pathogenesis of ABPA HLA associations: HLA-DR molecules (DR2, DR5, and possibly, DR4 or DR7) associated with susceptibility HLA-DQ2 molecules associated [slideshare.net]

Mooren's Ulcer

The same study found that only one out of 10 patients with another form of destructive sclerokeratitis expressed the HLA-DR17 allele and three expressed HLA-DQ2. [eyewiki.aao.org]

One study suggested that 83% of patients (n=12) with Mooren's ulcer were HLA-DR17 positive, and 83% were HLA-DQ2 positive, as compared to control populations where frequencies [eyewiki.aao.org]

HLA-DQ5 has also been found in increased frequencies in patients with Mooren's ulcer [7]. [eyewiki.aao.org]

Celiac Disease-Epilepsy-Cerebral Calcification Syndrome

It is associated with the HLA-DQ2 and HLA-DQ8 genes. [radiopaedia.org]

As for isolated CD, CEC is associated with the HLA-DQ2 and HLA-DQ8 genes. [orpha.net]

Moreover, CEC, as well as CD, is associated with HLA-DQ2 and HLA-DQ8 phenotype and genotype. [ncbi.nlm.nih.gov]

Familial Enteropathy with Villous Edema and IgG2 Deficiency

HLA typing for all first-degree relatives; do no further work-up on those who are negative for HLA-DQ2/8. [worldgastroenterology.org]

Others activate lamina propria T cells in the context of HLA-DQ2 or DQ8 molecules. [obgynkey.com]

In one of these studies, 30% of patients with abdominal symptoms suggestive of irritable bowel syndrome having the celiac-like HLA-DQ2 gene but no antibodies to gliadin in [celiac.com]

Bardet-Biedl Syndrome Type 15

The patient has also been shown to be HLA DQ2 antigen negative and DQ8 antigen positive. [hindawi.com]

Gluten Allergy

Thus, HLA-DQ2 or HLA-DQ8 is necessary for disease development but is not sufficient for disease development. [allergycliniclondon.co.uk]

“The vaccine is designed to target the 90 percent of celiac disease patients with the HLA-DQ2 genetic form of disease. [wellandgood.com]

DQ2 and HLA DQ8) Intestinal biopsy (for celiacs) I want to mention that one potential problem with testing is that gluten is made up of several hundred peptides and gliadin [amymyersmd.com]

Collagenous Sprue

None of the patients had ever shown celiac-specific antibodies, and all were negative for HLA-DQ2 and HLA-DQ8 phenotype. [celiac.com]

[…] a) Refer the patient for a dietary review b) Request a clonal analysis of the intraepithelial lymphocytes c) Refer for HLA DQ2/DQ8 testing d) Refer the patient for capsule [ueg.eu]

HLA haplotype showed the presence of HLA-DQ2. The patient underwent upper panendoscopy with multiple duodenal biopsies. [scielo.isciii.es]

Obstipation

HLA typing for all first-degree relatives; do no further work-up on those who are negative for HLA-DQ2/8. [web.archive.org]

Celiac disease is associated with HLA-DQ2 and -DQ8; HLA-DQ2 is present in approximately 95% of celiac disease patients of northern European descent, while the rest are carriers [web.archive.org]

ELISA/radioimmunoassay-based tests for detecting IgA anti-tTG or IgG anti-DGP should therefore be recommended in settings with low expertise. 5.6 HLA-DQ2/-DQ8 genotyping HLA-DQ2 [web.archive.org]

Autoimmune Enteropathy

The patients were HLA-DQ2 positive. IgA antigliadin and antiendomysial antibodies were not found in any of the patients. [ncbi.nlm.nih.gov]

Four patients had the celiac HLA-DQ2/DQ8 susceptibility genotype. [journals.plos.org]

HLA DQ2/DQ8 can bind gluten peptides after their prior modification by the CD autoantigen, tissue transglutaminase (TG2). [readbyqxmd.com]

Bardet-Biedl Syndrome Type 1

The patient has also been shown to be HLA DQ2 antigen negative and DQ8 antigen positive. [hindawi.com]

Alpha 2 Macroglobulin Deficiency

[…] the presence of HLA-DQ2 and -DQ8 CD risk alleles ( 24 ). [jn.nutrition.org]

B27 HLAD HLA DQ2-DQ8 HPA HPA HPL HPL Orm.Latt.Placent. [labtrastevere.it]

VAN DE KAMER (CUANTIFICACION) GRUPO SANGUINEO Y FACTOR RH HALOPERIDOL (BUTIROFERONA) HAPLOTIPOS HLA-DQ2 Y HLA-DQ8 EN ENFERMEDAD CELIACA HAPTOGLOBINA HCM (HEMOGLOBINA CORPUSCULAR [clinalab.es]

Alcoholic Cerebellar Degeneration

The HLA DQ2 has also been seen in a number of other autoimmune diseases including primary autoimmune cerebellar ataxia. [journals.plos.org]

Up to 90% of patients with celiac disease are HLA DQ2, the remaining have DQ8 or DQ1. NCVs can be normal or minimally abnormal axonal neuropathy. [neuroweb.us]

It also implies that there is a genetic susceptibility (HLA DQ2) for patients with ACAA, something that has not previously been reported. [journals.plos.org]

Addison Disease

More than 95 % of those with CD express HLA-DQ2 while the remainder expresses HLA-DQ8. [doi.org]

There is a strong linkage between CD and HLA-DQ2 and HLA-DQ8 haplotypes. [ncbi.nlm.nih.gov]

Studies show an association with HLA-DQ2 and HLA-DQ8, the same HLA haplotypes necessary for the presence of CD [ 18, 20 ]. [doi.org]

Food Intolerance

DH shares an high prevalence of HLA alleles DQ2 (90%) and DQ8 (5%) with CD[ 36 ]. [dx.doi.org]

HLA typing for all first-degree relatives; do no further work-up on those who are negative for HLA-DQ2/8. [web.archive.org]

Genetic studies have identified HLA-DQ2 and -DQ8 as the major determinants of susceptibility to CD. [dx.doi.org]

Holmes-Adie Syndrome

The patient was a homozygous carrier for HLA DQ2 antigen characteristic for celiac disease and heterozygous for HLA DR3 B8 frequent in autoimmune liver diseases. [ncbi.nlm.nih.gov]

Autoimmune Polyendocrine Syndrome Type 1

HLA-DQ2 can be found in 90% of patients with celiac disease and in 55% of patients with T1D, while HLA-DQ8 is present in approximately 10% and 70%, respectively[ 62 ]. [wjgnet.com]

Genetic Aspects Autoimmune Addison's is closely associated with the_ HLA-DR3_ haplotype; the highest risk genotype is HLA-DR3/4-DQ2/8, found in 30% of patients. [diapedia.org]

HLA DR3-DR5 Autoimmune thyroiditis HLA DR3-DQ2 Celiac disease HLA DR3-DQ2, DR4-DQ8 (DRB1 * 0404) Addison's disease MICA 4, 5, 6, and 9 GCT repeats (exon 5) Type 1A diabetes [liebertpub.com]

Congenital Malabsorption of Folic Acid

Others activate lamina propria T cells in the context of HLA-DQ2 or DQ8 molecules. [clinicalgate.com]

DQ2-negative celiac patients are invariably HLA DQ8 positive (DQA1*0301/DQB1*0302). [clinicalgate.com]

[…] the measurement of HLA DQ2 and/or DQ8 has a strong negative predictive value but a very weak positive predictive value for the diagnosis of celiac disease. [clinicalgate.com]

Dermatitis Vegetans

Patients with dermatitis herpetiformis have an increased expression of the HLA-A1, HLA-B8, HLA-DR3, and HLA-DQ2 haplotypes. [emedicine.medscape.com]

Both dermatitis herpetiformis and celiac disease (CD) are associated with an increased expression of HLA-A1, HLA-B8, HLA-DR3, and HLA-DQ2 haplotypes. [emedicine.medscape.com]

For HLA-DQ2, the association with dermatitis herpetiformis is 95-100%, versus 40% for control patients. [emedicine.medscape.com]