Bradykinesia: Causes & Reasons

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Possible Causes for Bradykinesia

Parkinson Disease

Table 1 Parkinson’s disease symptoms Bradykinesia Bradykinesia refers to slowness of movement and is the most characteristic clinical feature of PD, although it may also be [web.archive.org]

Rest tremor, bradykinesia, rigidity and loss of postural reflexes are generally considered the cardinal signs of PD. [dx.doi.org]

In a study assessing recordings from single cortical neurons in rats with haloperidol induced bradykinesia, a decrease in firing rates correlated with bradykinesia. 29 Functional [web.archive.org]

Shy-Drager Syndrome

While the limited and transient beneficial effect of levodopa on the bradykinesia in our case is possibly due to the progressive loss of striatal dopaminergic receptors seen [ncbi.nlm.nih.gov]

For patients afflicted with this condition, rigidity and bradykinesia are the primary extrapyramidal symptoms which are present. [ncbi.nlm.nih.gov]

A previously healthy 60 years old female patient presented with bradykinesia, postural instability and increased rigidity of both upper and lower limbs for 2 years and was [ncbi.nlm.nih.gov]

Progressive Supranuclear Palsy

UPDRS total motor scores and subscores for bradykinesia and axial motor deficits did not correlate with R2* values of the five brain regions. [ncbi.nlm.nih.gov]

PSP-corticobasal syndrome (PSP-CBS) is characterized by progressive, asymmetric dyspraxia, limb rigidity, bradykinesia and progressive postural instability. [orpha.net]

(iv) Bradykinesia: the presence of any mention of bradykinesia or motor slowing. [doi.org]

Juvenile Paralysis Agitans of Hunt

32 HP:0002067 9 parkinsonism 32 HP:0001300 Symptoms via clinical synopsis from OMIM: 57 Neuro: dysarthria gait disturbance tremor rigidity bradykinesia more Misc: onset in [malacards.org]

Slowness of motion (bradykinesia) is one of the classic symptoms of Parkinson's disease. [slideplayer.com]

Diseases related with Melanoma and Bradykinesia In the following list you will find some of the most common rare diseases related to Melanoma and Bradykinesia that can help [mendelian.co]

Dementia with Lewy Bodies

[…] clinical features include: recurrent visual hallucinations; cognitive fluctuations; REM sleep behaviour disorder; and one or more spontaeous cardinal features of parkinsonism: bradykinesia [bestpractice.bmj.com]

He showed bradykinesia and small step gait with supranuclear vertical gaze palsy, especially upward gaze palsy. He was started on levodopa therapy but without response. [ncbi.nlm.nih.gov]

The neuropsychiatric manifestations tend to precede the onset of bradykinesia, muscle rigidity, and other extrapyramidal signs. [icd9data.com]

Postencephalitic Parkinson Disease

Generally, when two of the four cardinal signs occur (tremor at rest, bradykinesia, rigidity or problems with balance), a diagnosis may be made and treatment initiated. [parkinsonsmi.org]

Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. [hon.ch]

Parkinson's disease is recognized by the presence of at least three of four cardinal signs: resting tremor, cogwheel rigidity, bradykinesia/akinesia, and postural reflex impairment [parkinsonsmi.org]

Parkinsonism

However, prior studies have examined parkinsonism (defined as having bradykinesia with at least rest tremor or postural instability) mostly in premutation carriers without [ucdavis.pure.elsevier.com]

Some patients present a moderate response to levodopa that improves bradykinesia and rigidity. [orpha.net]

Subtle “bradykinesia” has been reported to occur in the “normal elderly” population, but this may reflect a non-specific slowness rather than bradykinesia as defined above [movementdisorders.org]

Methylphenyltetrahydropyridine

[…] with lewy bodies Pathophysiology neurodegeneration of dopaminergic neurons e.g., substantia nigra pars compacta leads to bradykinesia due to distruption of basal ganglia [medbullets.com]

[…] tetrahydropyridine, analogs MTMP, PEPAP Neurology A potent neurotoxin–which has an effect much like Meperidine or Demerol—that acts on neuromelanin, producing parkinsonism Clinical Bradykinesia [medical-dictionary.thefreedictionary.com]

Clinically, PD is characterized by rest tremor, rigidity, bradykinesia, and gait impairment, known as the "cardinal features" of the disease. [flipper.diff.org]

Prion Disease

The first patient experienced progressive bradykinesia, ataxia, and slurred speech developing over a two-week period. [web.archive.org]

Gaucher Disease

Initially, 17 subjects were identified with Gaucher disease and l -DOPA refractory parkinsonian manifestations that included tremor, bradykinesia, rigidity, and often cognitive [jmg.bmj.com]

Additional noted trends were that subjects carrying mutations presented an average of 4 years earlier, were more likely to have a family history of PD, and had less bradykinesia [doi.org]

Hypothyroidism

Hypothyroidism presents with the following signs and symptoms: Cardiovascular The heart muscle slows down and contractility decreases therefore the cardiac output is also decreased. Bradycardia, decreased systolic and increased diastolic blood pressure, systemic hypotension and in some severe cases, pericardial[…] [symptoma.com]

Pallidopyramidal Syndrome

Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia. [malacards.org]

Parkinsonian-pyramidal syndrome Disease definition Parkinsonian-pyramidal syndrome is a rare, genetic, neurological disorder characterized by the association of both parkinsonian (i.e. bradykinesia [orpha.net]

Orpha Number: 171695 Definition Parkinsonian-pyramidal syndrome is a rare, genetic, neurological disorder characterized by the association of both parkinsonian (i.e. bradykinesia [malacards.org]

X-Linked Parkinsonism with Spasticity

UniProtKB/Swiss-Prot : 75 Parkinsonism with spasticity, X-linked: A syndrome characterized by parkinsonian features, such as cogwheel rigidity, resting tremor and bradykinesia [malacards.org]

UniProtKB/Swiss-Prot : 73 Parkinsonism with spasticity, X-linked: A syndrome characterized by parkinsonian features, such as cogwheel rigidity, resting tremor and bradykinesia [malacards.org]

Definition A syndrome characterized by parkinsonian features, such as cogwheel rigidity, resting tremor and bradykinesia, and variably penetrant spasticity. [uniprot.org]

Multiple Myeloma

Overview Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell. Plasma cells help you fight infections by making antibodies that recognize and attack germs. Multiple myeloma causes cancer cells to accumulate in the bone marrow, where they crowd out healthy blood cells. Rather than[…] [mayoclinic.org]

Secondary Parkinsonism

Bradykinesia Patients often experience bradykinesia, which is one of the cardinal feature of parkinsonism. Bradykinesia develops due to the involvement of basal ganglia. [medicaljoyworks.com]

On observing for 5 subsequent days, there was no improvement in her bradykinesia or rigidity. [mdsabstracts.org]

Department of neurology, Dong-A University College of Medicine Abstract Backgroud & Significance: Parkinsoinsm is characterized by clinical symptoms of igidity, bradykinesia [jkna.org]

Bradykinesia

Bradykinesia encompasses slowness, decreased movement amplitude, and dysrhythmia. [ncbi.nlm.nih.gov]

Abstract Correct assessment of bradykinesia is a key element in the diagnosis and monitoring of Parkinson's disease. [ncbi.nlm.nih.gov]

INTRODUCTION: Bradykinesia is usually assessed using clinical rating scales. [ncbi.nlm.nih.gov]

Classic Progressive Supranuclear Palsy Syndrome

PSP-CBS is characterized by progressive asymmetric dyspraxia, limb rigidity, bradykinesia, and progressive postural instability. [orpha.net]

PSP-corticobasal syndrome (PSP-CBS) is characterized by progressive, asymmetric dyspraxia, limb rigidity, bradykinesia and progressive postural instability. [orpha.net]

Summary Clinical description PSP-P is characterized by early parkinsonism, including limb bradykinesia, axial and limb rigidity and, in some patients, tremor, with some response [orpha.net]

Juvenile Huntington Disease

There was a predominance of rigidity and bradykinesia. [ncbi.nlm.nih.gov]

HUNTINGTON'S DISEASE (WESTPHAL VARIANT) A progressive neurodegenerative disorder characterized initially by bradykinesia and rigidity then choreiform movements. [endoflifecare.tripod.com]

On examination, the child had ataxic gait, bradykinesia, oculomotor apraxia, rigidity, and signs of cerebellar involvement. Fundus examination was normal. [pediatricneurosciences.com]

Striatonigral Degeneration

The main clinical features were bradykinesia and rigidity. He also showed pseudobulbar and pyramidal syndromes. [ncbi.nlm.nih.gov]

[…] that distinguished SND from PD were the early appearance of the following symptoms and signs: (a) severe and atypical progressive parkinsonism characterized by bilateral bradykinesia [ncbi.nlm.nih.gov]

The patient, a 55-year-old woman with progressive and relatively intractable rigidity and bradykinesia, particularly of the right side, was studied with brain MR scans and [ncbi.nlm.nih.gov]

Huntington Disease-Like Type 3

Huntington’s Disease Clinical Features - 3 • juvenile onsetjuvenile onset • rigidity, dystonia, bradykinesia, myoclonusrigidity, dystonia, bradykinesia, myoclonus • seizuresseizures [slideshare.net]

[…] the extremities, which interferes with function.As the disease progresses, chorea coexists with ,and gradually is replaced by, dystonia and parkinsonian features, such as bradykinesia [physio-pedia.com]

This slowing of movements is called bradykinesia. Swallowing problems are common if you have HD. [patient.info]

Primary Orthostatic Tremor

Information Links Trending Red Flags A-Z GP contract GP Training GP Locums GP Wellbeing Rigidity Impaired postural reflexes Abnormality of speech Nystagmus Irritability Jaundice Bradykinesia [gponline.com]

He had mild to moderate extrapyramidal rigidity of the limbs with asymmetric bradykinesia, more marked on the right. [jnnp.bmj.com]

After a dopa challenge (50 mg carbidopa and 200 mg levodopa) he exhibited a marked improvement of rigidity and bradykinesia. [jnnp.bmj.com]

Adult-Onset Dystonia - Parkinsonism

Parkinsonism refers to all clinical states characterized by tremor, muscle rigidity, slowed movement (bradykinesia) and often postural instability. [ncbi.nlm.nih.gov]

Symptoms worsen over time and include resting tremor, muscular rigidity, bradykinesia [abnormal slowness of movement], and postural instability [impaired balance and coordination [flybase.org]

Motor parkinsonian manifestations (bradykinesia, rigidity, and less frequently tremor) vary in severity and may appear later. [neuropathology-web.org]

Extrapyramidal Disorder

Bradykinesia and rigidity are additive in hindering movement and are usually present together. [dartmouth.edu]

Associated with rigidity & bradykinesia Slide 10: TREMORRhythmic, sinusoidal movement Differential Diagnosis: - Myoclonus - Asterixes - Tics (Guilles de la Tourette syndrome [authorstream.com]

Since this system regulates posture and skeletal muscle tone, a result is the characteristic bradykinesia of Parkinson's. [en.wikipedia.org]

Drug-Induced Dystonia

Parkinsonism Tremor, rigidity, mask-like facial expression, and/or bradykinesia Akathisia Restlessness and an internal feeling of unease Dystonia Abnormal tonic muscle contractions [pedemmorsels.com]

Parkinsonism and other medication-induced Parkinsonism Parkinsonian symptoms of mask-like facies, resting tremor, cogwheel rigidity, shuffling gait, and psychomotor retardation (bradykinesia [hopkinsguides.com]

[…] description RDP typically presents in childhood or early adulthood (but age of onset can range from 4-55 years) with the abrupt onset of dystonia along with parkinsonism (bradykinesia [orpha.net]

Carbon Monoxide-Induced Parkinsonism

Associate Professor Movement Disorders Section Department of Neurological Sciences Rush University Medical Center 2 Parkinson’s Disease, Motor Abnormalities Tremor Bradykinesia [slideplayer.com]

Bradykinesia — Slowness in initiating movement. Loss of Postural Reflexes — Poor posture and balance that may cause falls; gait or balance problems. [rwjuh.edu]

Bradykinesia. Slowness in starting movement. Postural instability. Poor posture and balance that may cause falls or gait problems. [elcaminohospital.org]

Pyramidal Tract Disorder

O, Alberts J, Machado A Abstract A fundamental challenge in the clinical care of Parkinson disease (PD) is the current dependence on subjective evaluations of tremor and bradykinesia [medworm.com]

It is characterised by rigidity (increased muscle tone), bradykinesia (slowing of movements) and tremors. [kenhub.com]

Affectation of which may result in bradykinesia or slow movements, lead-pipe rigidity, postural instability, mask like face, shuffling gait and resting tremor that are similar [healthfoxx.com]

Beta-Propeller Protein-Associated Neurodegeneration

Design/Methods: Examination revealed an alert, happy young woman with rigidity, dystonic posturing, and generalized bradykinesia. [neurology.org]

The group with predominant parkinsonism had characteristically bradykinesia, gait impairment, rigidity and altered postural reflexes. [mdsabstracts.org]

Parkinsonism can include unusually slow movement (bradykinesia), rigidity, tremors, an inability to hold the body upright and balanced (postural instability), and a shuffling [elbiruniblogspotcom.blogspot.no]

Mitochondrial Membrane Protein-Associated Neurodegeneration

These abnormalities include unusually slow movement (bradykinesia), muscle rigidity, involuntary trembling (tremors), and an inability to hold the body upright and balanced [ghr.nlm.nih.gov]

He also showed bradykinesia in all extremities. Apparently he showed no ataxia or no sensory impairment. The tendon reflexes were all normal. [omicsonline.org]

Hypomimia and bradykinesia were also noted. Eye fundus examination was normal. [pediatricneurosciences.com]

Huntington Disease-Like Type 1

This slowing of movements is called bradykinesia. Swallowing problems are common if you have HD. [patient.info]

[…] in offspring of an affected male Clinical Presentation Progressive neurodegenerative disorder Motor symptoms Tremor Chorea/choreoathetosis Slow ocular saccades Akinesia, bradykinesia [arupconsult.com]

Olivopontocerebellar Atrophy

A patient with olivopontocerebellar atrophy presented with an asymmetric parkinsonian syndrome consisting of right limb rigidity, bradykinesia, masked facies, and a hypophonic [ncbi.nlm.nih.gov]

A Japanese woman without a remarkable family history showed hand tremor at the age of 35 years, followed by bradykinesia, muscle rigidity, orthostatic hypotension, neurogenic [ncbi.nlm.nih.gov]

All patients develop at least some parkinsonian signs (bradykinesia, rigidity, irregular jerky postural tremor) in the course of the disease. [orpha.net]