Bradykinesia: Causes & Reasons

Possible Causes for Bradykinesia

Table 1 Parkinson’s disease symptoms Bradykinesia Bradykinesia refers to slowness of movement and is the most characteristic clinical feature of PD, although it may also be [web.archive.org]

Rest tremor, bradykinesia, rigidity and loss of postural reflexes are generally considered the cardinal signs of PD. [dx.doi.org]

In a study assessing recordings from single cortical neurons in rats with haloperidol induced bradykinesia, a decrease in firing rates correlated with bradykinesia. 29 Functional [web.archive.org]

Progressive Supranuclear Palsy

UPDRS total motor scores and subscores for bradykinesia and axial motor deficits did not correlate with R2* values of the five brain regions. [ncbi.nlm.nih.gov]

PSP-corticobasal syndrome (PSP-CBS) is characterized by progressive, asymmetric dyspraxia, limb rigidity, bradykinesia and progressive postural instability. [orpha.net]

(iv) Bradykinesia: the presence of any mention of bradykinesia or motor slowing. [doi.org]

Juvenile Parkinson Disease of Hunt

Diseases related with Melanoma and Bradykinesia In the following list you will find some of the most common rare diseases related to Melanoma and Bradykinesia that can help [mendelian.co]

32 HP:0002067 9 parkinsonism 32 HP:0001300 Symptoms via clinical synopsis from OMIM: 57 Neuro: dysarthria gait disturbance tremor rigidity bradykinesia more Misc: onset in [malacards.org]

Bradykinesia MedGen UID: 115925 •Concept ID: C0233565 • Sign or Symptom Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution [ncbi.nlm.nih.gov]

Shy-Drager Syndrome

While the limited and transient beneficial effect of levodopa on the bradykinesia in our case is possibly due to the progressive loss of striatal dopaminergic receptors seen [ncbi.nlm.nih.gov]

Specifically, Parkinson’s features include tremor, bradykinesia and rigid muscles, which lead to impaired posture and balance, as well as speech changes. [casereports.in]

A previously healthy 60 years old female patient presented with bradykinesia, postural instability and increased rigidity of both upper and lower limbs for 2 years and was [ncbi.nlm.nih.gov]

Dementia with Lewy Bodies

[…] clinical features include: recurrent visual hallucinations; cognitive fluctuations; REM sleep behaviour disorder; and one or more spontaeous cardinal features of parkinsonism: bradykinesia [bestpractice.bmj.com]

He showed bradykinesia and small step gait with supranuclear vertical gaze palsy, especially upward gaze palsy. He was started on levodopa therapy but without response. [ncbi.nlm.nih.gov]

The neuropsychiatric manifestations tend to precede the onset of bradykinesia, muscle rigidity, and other extrapyramidal signs. [icd9data.com]

Postencephalitic Parkinson Disease

Generally, when two of the four cardinal signs occur (tremor at rest, bradykinesia, rigidity or problems with balance), a diagnosis may be made and treatment initiated. [parkinsonsmi.org]

Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. [hon.ch]

Parkinson's disease is recognized by the presence of at least three of four cardinal signs: resting tremor, cogwheel rigidity, bradykinesia/akinesia, and postural reflex impairment [parkinsonsmi.org]

Parkinsonism

However, prior studies have examined parkinsonism (defined as having bradykinesia with at least rest tremor or postural instability) mostly in premutation carriers without [ucdavis.pure.elsevier.com]

Some patients present a moderate response to levodopa that improves bradykinesia and rigidity. [orpha.net]

Subtle “bradykinesia” has been reported to occur in the “normal elderly” population, but this may reflect a non-specific slowness rather than bradykinesia as defined above [movementdisorders.org]

Methylphenyltetrahydropyridine

[…] with lewy bodies Pathophysiology neurodegeneration of dopaminergic neurons e.g., substantia nigra pars compacta leads to bradykinesia due to distruption of basal ganglia [medbullets.com]

[…] tetrahydropyridine, analogs MTMP, PEPAP Neurology A potent neurotoxin–which has an effect much like Meperidine or Demerol—that acts on neuromelanin, producing parkinsonism Clinical Bradykinesia [medical-dictionary.thefreedictionary.com]

Clinically, PD is characterized by rest tremor, rigidity, bradykinesia, and gait impairment, known as the "cardinal features" of the disease. [flipper.diff.org]

Prion Disease

The first patient experienced progressive bradykinesia, ataxia, and slurred speech developing over a two-week period. [web.archive.org]

Gaucher Disease

Initially, 17 subjects were identified with Gaucher disease and l -DOPA refractory parkinsonian manifestations that included tremor, bradykinesia, rigidity, and often cognitive [jmg.bmj.com]

Additional noted trends were that subjects carrying mutations presented an average of 4 years earlier, were more likely to have a family history of PD, and had less bradykinesia [doi.org]

Hypothyroidism

Hypothyroidism Other names Underactive thyroid, low thyroid, hypothyreosis Molecular structure of thyroxine, the deficiency of which causes the symptoms of hypothyroidism Pronunciation [1][2] Specialty Endocrinology Symptoms Poor ability to tolerate cold, feeling tired, constipation, depression, weight gain[3][…] [en.wikipedia.org]

X-Linked Parkinsonism with Spasticity

UniProtKB/Swiss-Prot : 73 Parkinsonism with spasticity, X-linked: A syndrome characterized by parkinsonian features, such as cogwheel rigidity, resting tremor and bradykinesia [malacards.org]

UniProtKB/Swiss-Prot : 75 Parkinsonism with spasticity, X-linked: A syndrome characterized by parkinsonian features, such as cogwheel rigidity, resting tremor and bradykinesia [malacards.org]

Definition A syndrome characterized by parkinsonian features, such as cogwheel rigidity, resting tremor and bradykinesia, and variably penetrant spasticity. [uniprot.org]

Pallido-Pyramidal Syndrome

Diseases related with Muscle weakness and Bradykinesia In the following list you will find some of the most common rare diseases related to Muscle weakness and Bradykinesia [mendelian.co]

Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia. [malacards.org]

[…] cases Rigidity Common - Between 50% and 80% cases Accelerate your rare disease diagnosis with us Learn more Other less frequent symptoms Patients with Muscle weakness and Bradykinesia [mendelian.co]

Multiple Myeloma

Overview Plasma cell neoplasms occur when abnormal plasma cells form cancerous tumors in bone or soft tissue. When there is only one tumor, the disease is called a plasmacytoma. When there are multiple tumors, it is called multiple myeloma. Explore the links on this page to learn more about multiple myeloma treatment,[…] [cancer.gov]

Secondary Parkinsonism

Bradykinesia Patients often experience bradykinesia, which is one of the cardinal feature of parkinsonism. Bradykinesia develops due to the involvement of basal ganglia. [medicaljoyworks.com]

On observing for 5 subsequent days, there was no improvement in her bradykinesia or rigidity. [mdsabstracts.org]

Department of neurology, Dong-A University College of Medicine Abstract Backgroud & Significance: Parkinsoinsm is characterized by clinical symptoms of igidity, bradykinesia [jkna.org]

Bradykinesia

Writing becomes more difficult for patients suffering from bradykinesia. © Licence Creative Commons Bradykinesia - 1 Photo [futura-sciences.us]

Learn about this topic in these articles: antipsychotic agents In mental disorder: Antipsychotic agents …include tremor of the limbs, bradykinesia (slowness of movement with [britannica.com]

In PD, facial bradykinesia is primarily mediated by basal ganglia dysfunction whereas in PSP, facial bradykinesia is a consequence of a widespread degeneration involving the [ncbi.nlm.nih.gov]

Progressive Supranuclear Palsy Type 2

PSP-CBS is characterized by progressive asymmetric dyspraxia, limb rigidity, bradykinesia, and progressive postural instability. [orpha.net]

PSP-corticobasal syndrome (PSP-CBS) is characterized by progressive, asymmetric dyspraxia, limb rigidity, bradykinesia and progressive postural instability. [orpha.net]

Summary Clinical description PSP-P is characterized by early parkinsonism, including limb bradykinesia, axial and limb rigidity and, in some patients, tremor, with some response [orpha.net]

Striatonigral Degeneration

The main clinical features were bradykinesia and rigidity. He also showed pseudobulbar and pyramidal syndromes. [ncbi.nlm.nih.gov]

[…] that distinguished SND from PD were the early appearance of the following symptoms and signs: (a) severe and atypical progressive parkinsonism characterized by bilateral bradykinesia [ncbi.nlm.nih.gov]

The patient, a 55-year-old woman with progressive and relatively intractable rigidity and bradykinesia, particularly of the right side, was studied with brain MR scans and [ncbi.nlm.nih.gov]

Juvenile Huntington Disease

There was a predominance of rigidity and bradykinesia. [ncbi.nlm.nih.gov]

HUNTINGTON'S DISEASE (WESTPHAL VARIANT) A progressive neurodegenerative disorder characterized initially by bradykinesia and rigidity then choreiform movements. [endoflifecare.tripod.com]

On examination, the child had ataxic gait, bradykinesia, oculomotor apraxia, rigidity, and signs of cerebellar involvement. Fundus examination was normal. [pediatricneurosciences.com]

Adult-Onset Dystonia - Parkinsonism

Parkinsonism refers to all clinical states characterized by tremor, muscle rigidity, slowed movement (bradykinesia) and often postural instability. [ncbi.nlm.nih.gov]

Symptoms worsen over time and include resting tremor, muscular rigidity, bradykinesia [abnormal slowness of movement], and postural instability [impaired balance and coordination [flybase.org]

Motor parkinsonian manifestations (bradykinesia, rigidity, and less frequently tremor) vary in severity and may appear later. [neuropathology-web.org]

Extrapyramidal Disorder

Bradykinesia and rigidity are additive in hindering movement and are usually present together. [dartmouth.edu]

Since this system regulates posture and skeletal muscle tone, a result is the characteristic bradykinesia of Parkinson's. [en.wikipedia.org]

Associated with rigidity & bradykinesia Slide 10: TREMORRhythmic, sinusoidal movement Differential Diagnosis: - Myoclonus - Asterixes - Tics (Guilles de la Tourette syndrome [authorstream.com]

Pyramidal Tract Disorder

O, Alberts J, Machado A Abstract A fundamental challenge in the clinical care of Parkinson disease (PD) is the current dependence on subjective evaluations of tremor and bradykinesia [medworm.com]

It is characterised by rigidity (increased muscle tone), bradykinesia (slowing of movements) and tremors. [kenhub.com]

Affectation of which may result in bradykinesia or slow movements, lead-pipe rigidity, postural instability, mask like face, shuffling gait and resting tremor that are similar [healthfoxx.com]

Encephalitis Lethargica

rigidity and rest tremor), two had bradykinesia with postural instability, two had bradykinesia with rigidity, and two had bradykinesia with rest tremor. [brain.oxfordjournals.org]

Bradykinesia, rigidity Oculogyric crises, hemiballismus Mutism, disinhibition, compulsive touching Ophthalmoplegia, hiccough 10, F Hypersomnolence Present Bradykinesia – [brain.oxfordjournals.org]

Beta-Propeller Protein-Associated Neurodegeneration

Design/Methods: Examination revealed an alert, happy young woman with rigidity, dystonic posturing, and generalized bradykinesia. [neurology.org]

Parkinsonism can include unusually slow movement (bradykinesia), rigidity, tremors, an inability to hold the body upright and balanced (postural instability), and a shuffling [elbiruniblogspotcom.blogspot.no]

The group with predominant parkinsonism had characteristically bradykinesia, gait impairment, rigidity and altered postural reflexes. [mdsabstracts.org]

Huntington Disease-Like Type 3

[…] the extremities, which interferes with function.As the disease progresses, chorea coexists with ,and gradually is replaced by, dystonia and parkinsonian features, such as bradykinesia [physio-pedia.com]

This slowing of movements is called bradykinesia. Swallowing problems are common if you have HD. [patient.info]

Huntington’s Disease Clinical Features - 3 • juvenile onsetjuvenile onset • rigidity, dystonia, bradykinesia, myoclonusrigidity, dystonia, bradykinesia, myoclonus • seizuresseizures [slideshare.net]

Drug-Induced Dystonia

Parkinsonism and other medication-induced Parkinsonism Parkinsonian symptoms of mask-like facies, resting tremor, cogwheel rigidity, shuffling gait, and psychomotor retardation (bradykinesia [hopkinsguides.com]

Parkinsonism Tremor, rigidity, mask-like facial expression, and/or bradykinesia Akathisia Restlessness and an internal feeling of unease Dystonia Abnormal tonic muscle contractions [pedemmorsels.com]

[…] description RDP typically presents in childhood or early adulthood (but age of onset can range from 4-55 years) with the abrupt onset of dystonia along with parkinsonism (bradykinesia [orpha.net]

Huntington Disease-Like Type 1

This slowing of movements is called bradykinesia. Swallowing problems are common if you have HD. [patient.info]

[…] in offspring of an affected male Clinical Presentation Progressive neurodegenerative disorder Motor symptoms Tremor Chorea/choreoathetosis Slow ocular saccades Akinesia, bradykinesia [arupconsult.com]

Mitochondrial Membrane Protein-Associated Neurodegeneration

He also showed bradykinesia in all extremities. Apparently he showed no ataxia or no sensory impairment. The tendon reflexes were all normal. [omicsonline.org]

These abnormalities include unusually slow movement (bradykinesia), muscle rigidity, involuntary trembling (tremors), and an inability to hold the body upright and balanced [ghr.nlm.nih.gov]

Hypomimia and bradykinesia were also noted. Eye fundus examination was normal. [pediatricneurosciences.com]

Neuroferritinopathy

She has brisk tendon reflexes with bradykinesia. [mdsabstracts.org]

Symptoms are restricted to the nervous system and include chorea, dystonia, bradykinesia, dystonic dysarthria, and Parkinsonian features. [orpha.net]

Muscle tone and strength was normal with brisk tendon reflexes and bradykinesia. [mdsabstracts.org]

COASY Protein-Associated Neurodegeneration

[…] neurodegeneration with brain iron accumulation 6, is related to neurodegeneration with brain iron accumulation 6, and has symptoms including muscle rigidity, paraparesis, spastic and bradykinesia [malacards.org]

[…] people have these symptoms Pes cavus High-arched foot 0001761 Percent of people who have these symptoms is not available through HPO Autosomal recessive inheritance 0000007 Bradykinesia [rarediseases.info.nih.gov]

[…] begin to function abnormally because the axons (which send signals from one nerve cell to another) are deteriorating Parkinsonism (symptoms similar to Parkinson’s disease) Bradykinesia [nbiacure.org]